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dc.contributor.authorDoi, Masaoen
dc.contributor.authorShimatani, Hiroyukien
dc.contributor.authorAtobe, Yutaen
dc.contributor.authorMurai, Iorien
dc.contributor.authorHayashi, Hidaen
dc.contributor.authorTakahashi, Yukarien
dc.contributor.authorFustin, Jean-Michelen
dc.contributor.authorYamaguchi, Yoshiakien
dc.contributor.authorKiyonari, Hiroshien
dc.contributor.authorKoike, Nobuyaen
dc.contributor.authorYagita, Kazuhiroen
dc.contributor.authorLee, Choogonen
dc.contributor.authorAbe, Manabuen
dc.contributor.authorSakimura, Kenjien
dc.contributor.authorOkamura, Hitoshien
dc.contributor.alternative土居, 雅夫ja
dc.contributor.alternative嶋谷, 寛之ja
dc.contributor.alternative跡部, 裕太ja
dc.contributor.alternative村井, 伊織ja
dc.contributor.alternative林, 煕達ja
dc.contributor.alternative高橋, ゆかりja
dc.contributor.alternativeFustin, Jean-Michelen
dc.contributor.alternative山口, 賀章ja
dc.contributor.alternative清成, 寛ja
dc.contributor.alternative小池, 宜也ja
dc.contributor.alternative八木田, 和弘ja
dc.contributor.alternativeLee, Choogonen
dc.contributor.alternative阿部, 学ja
dc.contributor.alternative崎村, 建司ja
dc.contributor.alternative岡村, 均ja
dc.date.accessioned2019-06-13T00:13:29Z-
dc.date.available2019-06-13T00:13:29Z-
dc.date.issued2019-06-12-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/2433/241740-
dc.description体内リズムの発現に必要なDNAのスイッチを発見 --蛋白質をコードしないノンコーディング領域のDNA配列が活躍--. 京都大学プレスリリース. 2019-06-12.ja
dc.description.abstractNon-coding cis-regulatory elements are essential determinants of development, but their exact impacts on behavior and physiology in adults remain elusive. Cis-element-based transcriptional regulation is believed to be crucial for generating circadian rhythms in behavior and physiology. However, genetic evidence supporting this model is based on mutations in the protein-coding sequences of clock genes. Here, we report generation of mutant mice carrying a mutation only at the E′-box cis-element in the promoter region of the core clock gene Per2. The Per2 E′-box mutation abolishes sustainable molecular clock oscillations and renders circadian locomotor activity and body temperature rhythms unstable. Without the E′-box, Per2 messenger RNA and protein expression remain at mid-to-high levels. Our work delineates the Per2 E′-box as a critical nodal element for keeping sustainable cell-autonomous circadian oscillation and reveals the extent of the impact of the non-coding cis-element in daily maintenance of animal locomotor activity and body temperature rhythmicity.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Science and Business Media LLCen
dc.rights© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectCircadian rhythmsen
dc.subjectGene regulationen
dc.titleNon-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicityen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleNature Communicationsen
dc.identifier.volume10-
dc.relation.doi10.1038/s41467-019-10532-2-
dc.textversionpublisher-
dc.identifier.artnum2563-
dc.identifier.pmid31189882-
dc.relation.urlhttp://www.kyoto-u.ac.jp/ja/research/research_results/2019/190612_1.html-
dcterms.accessRightsopen access-
datacite.awardNumber15H05933-
datacite.awardNumber17H01524-
datacite.awardNumber18H04015-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
jpcoar.funderName.alternativeJapan Society for the Promotion of Science (JSPS)en
出現コレクション:学術雑誌掲載論文等

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