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dc.contributor.author | Matsuzaki, Tadanobu | en |
dc.contributor.author | Yoshihara, Toru | en |
dc.contributor.author | Ohtsuka, Toshiyuki | en |
dc.contributor.author | Kageyama, Ryoichiro | en |
dc.contributor.alternative | 松崎, 公信 | ja |
dc.contributor.alternative | 吉原, 亨 | ja |
dc.contributor.alternative | 大塚, 俊之 | ja |
dc.contributor.alternative | 影山, 龍一郎 | ja |
dc.date.accessioned | 2019-06-13T02:01:02Z | - |
dc.date.available | 2019-06-13T02:01:02Z | - |
dc.date.issued | 2019-06-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2433/241746 | - |
dc.description.abstract | Hes1 regulates the maintenance and proliferation of neural stem/progenitor cells as an essential effector of the Notch signaling pathway. Although Notch signaling is also involved in the functions of mature neurons in learning and memory and in the risk factors for mental disorders such as schizophrenia and bipolar disorder, the in-vivo role of Hes1 in mature neurons remains unknown. Here, we found that Hes1 is expressed by subsets of both excitatory and inhibitory neurons in the adult mouse brain, and that Hes1 expression is induced by neuronal stimulation. Furthermore, inactivation of Hes1 in excitatory neurons resulted in abnormal fear and anxiety behaviors concomitantly with higher neuronal excitability in the amygdala, while inactivation of Hes1 in inhibitory neurons resulted in increased sociability and perseverative tendencies. These results indicated that Hes1 is functionally important for normal behaviors not only in excitatory neurons but also in inhibitory neurons in the adult brain. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | en |
dc.rights | © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.subject | Fear conditioning | en |
dc.subject | Social behaviour | en |
dc.title | Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Scientific Reports | en |
dc.identifier.volume | 9 | - |
dc.relation.doi | 10.1038/s41598-019-44698-y | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 8251 | - |
dc.identifier.pmid | 31160641 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 16H06480 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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