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Title: Sedative effects of the essential oil and headspace air of Ocimum basilicum by inhalation in mice
Authors: Hirai, Miho
Ito, Michiho
Author's alias: 伊藤, 美千穂
Keywords: Sedative
Ocimum basilicum
Issue Date: Jan-2018
Publisher: Springer Science and Business Media LLC
Journal title: Journal of Natural Medicines
Volume: 73
Issue: 1
Start page: 283
End page: 288
Abstract: The sedative effects of the essential oil released by living Ocimum basilicum (basil) plants were investigated using a mouse activity monitoring system. Ocimum basilicum plants were grown in a hydroponic chamber, and either the headspace air from the hydroponic chamber or the essential oil extracted from mature plants was administered by the inhalation route to mice in an open field test. The most effective dose of O. basilicum essential oil for reducing the locomotor activity of the mice was found to be 4.0 × 10⁻³ mg per cage. The headspace air was administered to mice held in a glass cage via a Teflon tube connected to a hydroponic chamber containing O. basilicum plants. A significant decrease in locomotor activity was observed when the hydroponic chamber contained nine plants. The results of this study demonstrate that the headspace air of living basil plants could effectively reduce the locomotor activity of mice.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Journal of Natural Medicines. The final authenticated version is available online at:
The full-text file will be made open to the public on 20 October 2019 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1007/s11418-018-1253-3
Appears in Collections:Journal Articles

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