ダウンロード数: 278
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.cellsig.2019.05.014.pdf | 3.62 MB | Adobe PDF | 見る/開く |
タイトル: | The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions |
著者: | Teramoto, Koji Katoh, Hironori https://orcid.org/0000-0002-8191-8117 (unconfirmed) |
著者名の別形: | 加藤, 裕教 |
キーワード: | EphA2 xCT Amino acid transporter RSK Glioblastoma Glucose |
発行日: | Oct-2019 |
出版者: | Elsevier Inc. |
誌名: | Cellular Signalling |
巻: | 62 |
論文番号: | 109329 |
抄録: | EphA2, which belongs to the Eph family of receptor tyrosine kinases, is overexpressed in a variety of human cancers. Serine 897 (S897) phosphorylation of EphA2 is known to promote cancer cell migration and proliferation in a ligand-independent manner. In this study, we show that glucose deprivation induces S897 phosphorylation of EphA2 in glioblastoma cells. The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. Furthermore, depletion of EphA2 in glioblastoma cells leads to decreased cell viability under glucose starvation. Our results suggest a role of EphA2 in glioblastoma cell viability under glucose-limited conditions. |
著作権等: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 October 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/242982 |
DOI(出版社版): | 10.1016/j.cellsig.2019.05.014 |
PubMed ID: | 31152846 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。