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Title: The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions
Authors: Teramoto, Koji
Katoh, Hironori  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 加藤, 裕教
Keywords: EphA2
Amino acid transporter
Issue Date: Oct-2019
Publisher: Elsevier Inc.
Journal title: Cellular Signalling
Volume: 62
Thesis number: 109329
Abstract: EphA2, which belongs to the Eph family of receptor tyrosine kinases, is overexpressed in a variety of human cancers. Serine 897 (S897) phosphorylation of EphA2 is known to promote cancer cell migration and proliferation in a ligand-independent manner. In this study, we show that glucose deprivation induces S897 phosphorylation of EphA2 in glioblastoma cells. The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. Furthermore, depletion of EphA2 in glioblastoma cells leads to decreased cell viability under glucose starvation. Our results suggest a role of EphA2 in glioblastoma cell viability under glucose-limited conditions.
Rights: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 1 October 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.cellsig.2019.05.014
PubMed ID: 31152846
Appears in Collections:Journal Articles

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