ダウンロード数: 124
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.isci.2018.02.001.pdf | 2.27 MB | Adobe PDF | 見る/開く |
タイトル: | Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje Cells |
著者: | Ohtsuki, Gen https://orcid.org/0000-0003-3004-5886 (unconfirmed) Hansel, Christian |
著者名の別形: | 大槻, 元 |
発行日: | 23-Mar-2018 |
出版者: | Elsevier BV |
誌名: | iScience |
巻: | 1 |
開始ページ: | 49 |
終了ページ: | 54 |
抄録: | Neurons store information and participate in memory engrams as a result of experience-dependent changes in synaptic weights and in membrane excitability. Here, we examine excitatory postsynaptic potential (EPSP) amplitude and neuronal excitability in relation to these two mechanisms of plasticity. We analyze somato-dendritic double-patch recordings from cerebellar Purkinje cells while inducing intrinsic, SK2 channel-dependent plasticity or blocking SK channels with bath application of apamin. Both manipulations increase the build-up of EPSP amplitudes during an EPSP train and enhance the number of EPSP-evoked spikes, yielding insights into the mechanistic contribution of EPSP amplitude to single spikes and spike bursts. EPSP amplitude has an impact on whether spikes are fired or not, but direct measures of excitability (spike threshold/AHP) are better predictors of whether individual spikes or spike bursts are fired. Our findings show that Purkinje cell spiking is synaptically driven but that burst firing is gated by SK2 channel modulation and plasticity. |
著作権等: | © 2018 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/244019 |
DOI(出版社版): | 10.1016/j.isci.2018.02.001 |
PubMed ID: | 29888747 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。