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Title: Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors
Authors: Sakata, Akihiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid (unconfirmed)
Kunieda, Takeharu
Minamiguchi, Sachiko  kyouindb  KAKEN_id
Kido, Aki
Sakashita, Naotaka
Miyamoto, Susumu
Togashi, Kaori
Keywords: amide proton transfer imaging
chemical exchange saturation transfer
magnetic resonance imaging
magnetic resonance spectroscopy
Issue Date: Sep-2017
Publisher: Wiley
Journal title: Journal of magnetic resonance imaging : JMRI
Volume: 46
Issue: 3
Start page: 732
End page: 739
Abstract: [Purpose]To explore the relationship among parameters of magnetic resonance spectroscopy (MRS) and amide proton transfer (APT) imaging, and to assess the diagnostic performance of MRS and APT imaging for grading brain tumors in comparison with contrast enhancement of conventional MRI for preoperative grading in patients with brain tumor. [Materials and Methods]Institutional Review Board approval and written informed consent were obtained. Forty‐one patients with suspected brain tumors were enrolled in the study. Single‐voxel MRS and 2D APT imaging of the same slice level were conducted using a 3T MRI scanner. Positive or negative contrast enhancement on T1‐weighted images was assessed by two neuroradiologists. Correlations among metabolite concentrations, metabolite ratios, and calculated histogram parameters, including mean APT (APTmean) and the 90th percentile of APT (APT90) were assessed using Spearman's correlation coefficient. Diagnostic performance was evaluated with receiver operating characteristic (ROC) curve analysis for contrast enhancement and MRS and APT imaging. Values of P < 0.05 were considered statistically significant. [Results]Positive correlations with statistical significance were found between total concentration of choline (Cho) and APT90 (r = 0.49), and between Cho/creatine (Cr) and APTmean (r = 0.65) as well as APT90 (r = 0.49). A negative correlation with statistical significance was observed between NAA/Cr and APTmean (r = −0.52). According to ROC curves, Cho/Cr, APTmean, APT90, demonstrated higher area under the curve (AUC) values than that of contrast enhancement in grading gliomas. [Conclusion]Significant correlations were observed between metabolite concentrations and ratios on MRS and APT values. MRS and APT imaging showed comparable diagnostic capability for grading brain tumors, suggesting that both MRS and APT imaging offer potential for quantitatively assessing similar biological characteristics in brain tumors on noncontrast MRI.
Rights: This is the peer reviewed version of the following article: ['JMRI' 46(3) 732-739], which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
The full-text file will be made open to the public on 14 August 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1002/jmri.25597
PubMed ID: 28252822
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