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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| md17060353.pdf | 1.5 MB | Adobe PDF | 見る/開く |
| タイトル: | Kabirimine, a New Cyclic Imine from an Okinawan Dinoflagellate |
| 著者: | Hermawan, Idam Higa, Mikako Hutabarat, Philipus Uli Basa Fujiwara, Takeshi Akiyama, Kiyotaka Kanamoto, Akihiko Haruyama, Takahiro Kobayashi, Nobuyuki Higashi, Masahiro   https://orcid.org/0000-0001-9829-389X (unconfirmed)Suda, Shoichiro Tanaka, Junichi |
| 著者名の別形: | 東, 雅大 |
| キーワード: | cyclic imine dinoflagellate respiratory syncytial virus (RSV) portimine kabirimine |
| 発行日: | Jun-2019 |
| 出版者: | MDPI AG |
| 誌名: | Marine drugs |
| 巻: | 17 |
| 号: | 6 |
| 論文番号: | 353 |
| 抄録: | On our quest for new bioactive molecules from marine sources, two cyclic imines (1, 2) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound 1 was identified as a known molecule portimine, while 2 was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of 1 was determined by crystallographic work and chiral derivatization, whereas the structure of 2 was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound 1 showed potent cytotoxicity (CC₅₀ < 0.097 µM) against HEp2 cells, while 2 exhibited moderate antiviral activity against RSV with IC₅₀ = 4.20 µM (95% CI 3.31–5.33). |
| 著作権等: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| URI: | http://hdl.handle.net/2433/245467 |
| DOI(出版社版): | 10.3390/md17060353 |
| PubMed ID: | 31200525 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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