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09168451.2019.1667222.pdf | 9.93 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Irie, Kazuhiro | en |
dc.contributor.alternative | 入江, 一浩 | ja |
dc.date.accessioned | 2020-03-02T05:33:09Z | - |
dc.date.available | 2020-03-02T05:33:09Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | http://hdl.handle.net/2433/245866 | - |
dc.description.abstract | Recent investigations suggest that soluble oligomeric amyloid β (Aβ) species may be involved in early onset of Alzheimer’s disease (AD). Using systematic proline replacement, solid-state NMR, and ESR, we identified a toxic turn at position 22 and 23 of Aβ42, the most potent neurotoxic Aβ species. Through radicalization, the toxic turn can induce formation of the C-terminal hydrophobic core to obtain putative Aβ42 dimers and trimers. Synthesized dimer and trimer models showed that the C-terminal hydrophobic core plays a critical role in the formation of high molecular weight oligomers with neurotoxicity. Accordingly, an anti-toxic turn antibody (24B3) that selectively recognizes a toxic dimer model of E22P-Aβ42 was developed. Sandwich enzyme-linked immunosorbent assay with 24B3 and 82E1 detected a significantly higher ratio of Aβ42 with a toxic turn to total Aβ42 in cerebrospinal fluid of AD patients compared with controls, suggesting that 24B3 could be useful for early onset of AD diagnosis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japan Society for Bioscience Biotechnology and Agrochemistry | en |
dc.rights | This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience, Biotechnology and Biochemistry on 20 September 2019, available online: http://www.tandfonline.com/10.1080/09168451.2019.1667222. | en |
dc.rights | The full-text file will be made open to the public on 20 September 2020 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Alzheimer’s disease | en |
dc.subject | amyloid β | en |
dc.subject | antibody | en |
dc.subject | protein kinase C | en |
dc.subject | solid-phase peptide synthesis | en |
dc.title | New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Bioscience, Biotechnology and Biochemistry | - |
dc.identifier.volume | 84 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 16 | - |
dc.relation.doi | 10.1080/09168451.2019.1667222 | - |
dc.textversion | author | - |
dc.address | Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University | en |
dc.identifier.pmid | 31538538 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2020-10-20 | - |
datacite.awardNumber | 26221202 | - |
datacite.awardNumber | 19H00921 | - |
datacite.awardNumber | 21258015 | - |
datacite.awardNumber | 18208011 | - |
datacite.awardNumber | 16380080 | - |
datacite.awardNumber | 13460048 | - |
datacite.awardNumber | 11660109 | - |
datacite.awardNumber | 17H0640 | - |
datacite.awardNumber | 2310201 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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