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ファイル | 記述 | サイズ | フォーマット | |
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j.bbamem.2020.183233.pdf | 16.47 MB | Adobe PDF | 見る/開く |
タイトル: | Aβ–ganglioside interactions in the pathogenesis of Alzheimer's disease |
著者: | Matsuzaki, Katsumi ![]() ![]() ![]() |
著者名の別形: | 松﨑, 勝巳 |
キーワード: | Alzheimer's disease Amyloid β-protein Gangliosides Monosialoganglioside GM1 Amyloid fibrils Cytotoxicity |
発行日: | 1-Aug-2020 |
出版者: | Elsevier BV |
誌名: | Biochimica et biophysica acta |
巻: | 1862 |
号: | 8 |
論文番号: | 183233 |
抄録: | It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating evidence, both in vivo and in vitro, suggests that the binding of Aβ to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Aβ. This review summarizes the molecular details of the binding of Aβ to ganglioside-containing membranes and subsequent structural changes, as revealed by liposomal and cellular studies. Furthermore, mechanisms of cytotoxicity by aggregated Aβ are also discussed. |
著作権等: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The full-text file will be made open to the public on 1 August 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/251422 |
DOI(出版社版): | 10.1016/j.bbamem.2020.183233 |
PubMed ID: | 32142821 |
出現コレクション: | 学術雑誌掲載論文等 |
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