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Title: Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
Authors: Takeuchi, Akihide
Takahashi, Yuji
Iida, Kei  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7130-8705 (unconfirmed)
Hosokawa, Motoyasu
Irie, Koichiro
Ito, Mikako
Brown, J.B.
Ohno, Kinji
Nakashima, Kinichi
Hagiwara, Masatoshi  kyouindb  KAKEN_id
Author's alias: 武内, 章英
高橋, 勇次
飯田, 慶
細川, 元靖
入江, 浩一郎
伊藤, 美佳子
大野, 欽司
中島, 欽一
萩原, 正敏
Keywords: RNA-binding protein
quaking/Qk
neural stem cells/NSCs
glial precursor cells/GPCs
gliogenesis
mRNA stabilization
3′ untranslated region
regulon
endocytosis
RNA-seq
Issue Date: 13-Oct-2020
Publisher: Elsevier BV
Journal title: Stem Cell Reports
Volume: 15
Issue: 4
Start page: 883
End page: 897
Abstract: During brain development, neural stem cells (NSCs) initially produce neurons and change their fate to generate glias. While the regulation of neurogenesis is well characterized, specific markers for glial precursor cells (GPCs) and the master regulators for gliogenesis remain unidentified. Accumulating evidence suggests that RNA-binding proteins (RBPs) have significant roles in neuronal development and function, as they comprehensively regulate the expression of target genes in a cell-type-specific manner. We systematically investigated the expression profiles of 1, 436 murine RBPs in the developing mouse brain and identified quaking (Qk) as a marker of the putative GPC population. Functional analysis of the NSC-specific Qk-null mutant mouse revealed the key role of Qk in astrocyte and oligodendrocyte generation and differentiation from NSCs. Mechanistically, Qk upregulates gliogenic genes via quaking response elements in their 3′ untranslated regions. These results provide crucial directions for identifying GPCs and deciphering the regulatory mechanisms of gliogenesis from NSCs.
Description: 神経幹細胞の運命を決める分子を発見 --脳形成機構の解明と脳腫瘍や精神疾患の治療法に期待--. 京都大学プレスリリース. 2020-09-28.
Rights: © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/254692
DOI(Published Version): 10.1016/j.stemcr.2020.08.010
PubMed ID: 32976762
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2020-09-28-1
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