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タイトル: | Human Cell Atlas and cell-type authentication for regenerative medicine |
著者: | Panina, Yulia Karagiannis, Peter Kurtz, Andreas Stacey, Glyn N. Fujibuchi, Wataru |
著者名の別形: | 藤渕, 航 |
キーワード: | Classification and taxonomy Differentiation Stem-cell differentiation Stem-cell research Translational research |
発行日: | Sep-2020 |
出版者: | Springer Nature |
誌名: | Experimental & Molecular Medicine |
巻: | 52 |
号: | 9 |
開始ページ: | 1443 |
終了ページ: | 1451 |
抄録: | In modern biology, the correct identification of cell types is required for the developmental study of tissues and organs and the production of functional cells for cell therapies and disease modeling. For decades, cell types have been defined on the basis of morphological and physiological markers and, more recently, immunological markers and molecular properties. Recent advances in single-cell RNA sequencing have opened new doors for the characterization of cells at the individual and spatiotemporal levels on the basis of their RNA profiles, vastly transforming our understanding of cell types. The objective of this review is to survey the current progress in the field of cell-type identification, starting with the Human Cell Atlas project, which aims to sequence every cell in the human body, to molecular marker databases for individual cell types and other sources that address cell-type identification for regenerative medicine based on cell data guidelines. |
著作権等: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/2433/255580 |
DOI(出版社版): | 10.1038/s12276-020-0421-1 |
PubMed ID: | 32929224 |
出現コレクション: | 学術雑誌掲載論文等 |
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