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dc.contributor.author | Hagihara, Hideo | en |
dc.contributor.author | Murano, Tomoyuki | en |
dc.contributor.author | Ohira, Koji | en |
dc.contributor.author | Miwa, Miki | en |
dc.contributor.author | Nakamura, Katsuki | en |
dc.contributor.author | Miyakawa, Tsuyoshi | en |
dc.contributor.alternative | 中村, 克樹 | ja |
dc.date.accessioned | 2020-10-27T05:22:03Z | - |
dc.date.available | 2020-10-27T05:22:03Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | http://hdl.handle.net/2433/255651 | - |
dc.description.abstract | It is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. Recently, several studies reported that neural progenitor cells, neuroblasts, and immature neurons were detected in the hippocampus of elderly humans, based on the expressions of putative markers for these cells, claiming that this provides evidence of the persistence of AHN in humans. Herein, we briefly overview the phenomenon that we call “dematuration, ” in which mature neurons dedifferentiate to a pseudo-immature status and re-express the molecular markers of neural progenitor cells and immature neurons. Various conditions can easily induce dematuration, such as inflammation and hyper-excitation of neurons, and therefore, the markers for neural progenitor cells and immature neurons may not necessarily serve as markers for AHN. Thus, the aforementioned studies have not presented definitive evidence for the persistence of hippocampal neurogenesis throughout adult life in humans, and we would like to emphasize that those markers should be used cautiously when presented as evidence for AHN. Increasing AHN has been considered as a therapeutic target for Alzheimer’s disease (AD); however, given that immature neuronal markers can be re-expressed in mature adult neurons, independent of AHN, in various disease conditions including AD, strategies to increase the expression of these markers in the DG may be ineffective or may worsen the symptoms of such diseases. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.subject | Hippocampus | en |
dc.subject | Dentate gyrus | en |
dc.subject | Granule cells | en |
dc.subject | Dematuration | en |
dc.subject | Adult neurogenesis | en |
dc.title | Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Molecular brain | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.1186/s13041-019-0522-8 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 108 | - |
dc.address | Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University | en |
dc.address | Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University | en |
dc.address | Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University・Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women’s University | en |
dc.address | Cognitive Neuroscience Section, Primate Research Institute, Kyoto University | en |
dc.address | Cognitive Neuroscience Section, Primate Research Institute, Kyoto University | en |
dc.address | Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University | en |
dc.identifier.pmid | 31823803 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | JP16H06462 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName.alternative | Japan Society for the Promotion of Science (JSPS) | en |
出現コレクション: | 学術雑誌掲載論文等 |
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