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タイトル: | Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling |
著者: | Murashima-Suginami, A. Kiso, H. Tokita, Y. Mihara, E. Nambu, Y. Uozumi, R. Tabata, Y. Bessho, K. Takagi, J. Sugai, M. Takahashi, K. |
著者名の別形: | 村島-杉並, 亜希子 喜早, ほのか 時田, 義人 三原, 恵美子 南部, 由希子 魚住, 龍史 田畑, 泰彦 別所, 和久 高木, 淳一 菅井, 学 高橋, 克 |
発行日: | 10-Feb-2021 |
出版者: | American Association for the Advancement of Science (AAAS) |
誌名: | Science Advances |
巻: | 7 |
号: | 7 |
論文番号: | eabf1798 |
抄録: | Uterine sensitization–associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor–related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti–USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti–USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy. |
記述: | 先天性無歯症に対する分子標的薬の開発 --USAG-1を標的分子とした歯再生治療--. 京都大学プレスリリース. 2021-02-15. |
著作権等: | © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/261703 |
DOI(出版社版): | 10.1126/sciadv.abf1798 |
PubMed ID: | 33579703 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2021-02-15-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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