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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| pin.12925.pdf | 4.52 MB | Adobe PDF | 見る/開く |
| タイトル: | Experimental pathology by intravital microscopy and genetically encoded fluorescent biosensors |
| 著者: | Matsuda, Michiyuki    https://orcid.org/0000-0002-5876-9969 (unconfirmed)Terai, Kenta https://orcid.org/0000-0001-7638-3720 (unconfirmed) |
| 著者名の別形: | 松田, 道行 寺井, 健太 |
| キーワード: | biosensor experimental pathology FRET intravital microscop |
| 発行日: | Jun-2020 |
| 出版者: | wiley |
| 誌名: | Pathology International |
| 巻: | 70 |
| 号: | 7 |
| 開始ページ: | 379 |
| 終了ページ: | 390 |
| 抄録: | The invention of two-photon excitation microscopes widens the potential application of intravital microscopy (IVM) to the broad field of experimental pathology. Moreover, the recent development of fluorescent protein-based, genetically encoded biosensors provides an ideal tool to visualize the cell function in live animals. We start from a brief review of IVM with two-photon excitation microscopes and genetically encoded biosensors based on the principle of Förster resonance energy transfer (FRET). Then, we describe how IVM using biosensors has revealed the pathogenesis of several disease models. |
| 著作権等: | © 2020 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| URI: | http://hdl.handle.net/2433/263337 |
| DOI(出版社版): | 10.1111/pin.12925 |
| PubMed ID: | 32270554 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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