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タイトル: | Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making |
著者: | Oyama, Kei Hori, Yukiko Nagai, Yuji Miyakawa, Naohisa Mimura, Koki Hirabayashi, Toshiyuki Inoue, Ken-ichi Suhara, Tetsuya Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Higuchi, Makoto Minamimoto, Takafumi |
著者名の別形: | 小山, 佳 堀, 由紀子 永井, 裕司 宮川, 尚久 三村, 喬生 平林, 敏行 井上, 謙一 須原, 哲也 高田, 昌彦 樋口, 真人 南本, 敬史 |
発行日: | Jun-2021 |
出版者: | American Association for the Advancement of Science (AAAS) |
誌名: | Science Advances |
巻: | 7 |
号: | 26 |
論文番号: | eabg4246 |
抄録: | The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the distinctive roles of these prefronto-subcortical pathways remain elusive. Combining in vivo neuronal projection mapping with chemogenetic synaptic silencing, we reversibly dissected key pathways from dorsolateral part of the PFC (dlPFC) to the dorsal caudate (dCD) and lateral mediodorsal thalamus (MDl) individually in single monkeys. We found that silencing the bilateral dlPFC-MDl projections, but not the dlPFC-dCD projections, impaired performance in a spatial working memory task. Conversely, silencing the unilateral dlPFC-dCD projection, but not the unilateral dlPFC-MDl projection, altered preference in a decision-making task. These results revealed dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates. |
記述: | 「何を買うんだっけ」と「どれにしよう」を処理する2つの脳回路を明らかに --霊長類の生体脳で神経経路を可視化・操作する技術で解明、高次脳機能の理解へ大きく前進--. 京都大学プレスリリース. 2021-06-24. |
著作権等: | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/263918 |
DOI(出版社版): | 10.1126/sciadv.abg4246 |
PubMed ID: | 34162548 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2021-06-24 |
出現コレクション: | 学術雑誌掲載論文等 |
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