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dc.contributor.authorKanda, Junyaen
dc.contributor.authorHayashi, Hiromien
dc.contributor.authorRuggeri, Annalisaen
dc.contributor.authorKimura, Fumihikoen
dc.contributor.authorVolt, Fernandaen
dc.contributor.authorTakahashi, Satoshien
dc.contributor.authorKako, Shinichien
dc.contributor.authorTozatto-Maio, Karinaen
dc.contributor.authorYanada, Masamitsuen
dc.contributor.authorSanz, Guillermoen
dc.contributor.authorUchida, Naoyukien
dc.contributor.authorAngelucci, Emanueleen
dc.contributor.authorKato, Seikoen
dc.contributor.authorMohty, Mohamaden
dc.contributor.authorForcade, Edouarden
dc.contributor.authorTanaka, Masatsuguen
dc.contributor.authorSierra, Jorgeen
dc.contributor.authorOhta, Takanorien
dc.contributor.authorSaccardi, Riccardoen
dc.contributor.authorFukuda, Takahiroen
dc.contributor.authorIchinohe, Tatsuoen
dc.contributor.authorKimura, Takafumien
dc.contributor.authorRocha, Vandersonen
dc.contributor.authorOkamoto, Shinichiroen
dc.contributor.authorNagler, Arnonen
dc.contributor.authorAtsuta, Yoshikoen
dc.contributor.authorGluckman, Elianeen
dc.contributor.alternative諫田, 淳也ja
dc.contributor.alternative林, 裕美ja
dc.contributor.alternative木村, 文彦ja
dc.contributor.alternative高橋, 聡ja
dc.contributor.alternative賀古, 真一ja
dc.contributor.alternative柳田, 正光ja
dc.contributor.alternative内田, 直之ja
dc.contributor.alternative加藤, せい子ja
dc.contributor.alternative田中, 正嗣ja
dc.contributor.alternative太田, 貴徳ja
dc.contributor.alternative福田, 隆浩ja
dc.contributor.alternative一戸, 辰夫ja
dc.contributor.alternative岡本, 真一郎ja
dc.contributor.alternative熱田, 由子ja
dc.date.accessioned2022-01-06T07:23:39Z-
dc.date.available2022-01-06T07:23:39Z-
dc.date.issued2022-01-
dc.identifier.urihttp://hdl.handle.net/2433/267213-
dc.description急性白血病治療における臍帯血移植後の合併症が及ぼす予後への影響 --国際共同研究から明らかになった日欧での違い--. 京都大学プレスリリース. 2021-10-19.ja
dc.description.abstractThe impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3, 690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0–I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.en
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41409-021-01479-4.en
dc.rightsThe full-text file will be made open to the public on 11 April 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。en
dc.subjectEpidemiologyen
dc.subjectRisk factorsen
dc.titleThe impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populationsen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleBone Marrow Transplantationen
dc.identifier.volume57-
dc.identifier.issue1-
dc.identifier.spage57-
dc.identifier.epage64-
dc.relation.doi10.1038/s41409-021-01479-4-
dc.textversionauthor-
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto Universityen
dc.addressDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University; Eurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monacoen
dc.addressEurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monaco; Haematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Scientific Instituteen
dc.addressDivision of Hematology, Department of Internal Medicine, National Defense Medical Collegeen
dc.addressEurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monacoen
dc.addressDivision of Molecular Therapy, The Advanced Clinical Research Center The Institute of Medical Science, The University of Tokyoen
dc.addressDivision of Hematology, Jichi Medical University Saitama Medical Centeren
dc.addressEurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monaco; Faculdade de Medicina de Ribeirão Preto, Universidade de São Pauloen
dc.addressDepartment of Hematology and Cell Therapy, Aichi Cancer Centeren
dc.addressHematology Department, Hospital Universitario y Politécnico La Fe; CIBERONCen
dc.addressDepartment of Hematology, Toranomon Hospitalen
dc.addressHematology and Transplant Center, IRCCS Ospedale Policlinico San Martinoen
dc.addressDepartment of Hematology/Oncology, The Institute of Medical Science, The University of Tokyoen
dc.addressService d’Hématologie Clinique et de Thérapie cellulaire, APHP, Hôpital Saint Antoine; Sorbonne Universityen
dc.addressCHU Bordeaux, service d’hematologie et therapie cellulaireen
dc.addressDepartment of Hematology, Kanagawa Cancer Centeren
dc.addressHospital Santa Creu i Sant Pau Hematology Department, Barcelonaen
dc.addressDepartment of Internal Medicine, Kitakyushu Municipal Medical Centeren
dc.addressAzienda Ospedaliera Universitaria Careggi Cell Therapy and Transfusion Medicine Uniten
dc.addressHematopoietic Stem Cell Transplantation Division, National Cancer Center Hospitalen
dc.addressDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima Universityen
dc.addressPreparation Department, Japanese Red Cross Kinki Block Blood Centeren
dc.addressEurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monacoen
dc.addressDivision of Hematology, Department of Medicine, Keio University School of Medicineen
dc.addressDivision of Hematology and Bone Marrow Transplantation, The Chaim Sheba Medical Center; EBMT Data Office, Hôpital Saint Antoineen
dc.addressJapanese Data Center for Hematopoietic Cell Transplantationen
dc.addressEurocord, Hospital Saint Louis, AP-HP, IUH University Paris VII; Monacord, Centre Scientifique de Monacoen
dc.identifier.pmid34635798-
dc.relation.urlhttps://www.kyoto-u.ac.jp/ja/research-news/2021-10-19-1-
dcterms.accessRightsopen access-
datacite.date.available2022-04-11-
datacite.awardNumber18K08325-
datacite.awardNumber21K08391-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08325/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08391/-
dc.identifier.pissn0268-3369-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitle臨床データ解析による臍帯血移植成績向上のための国際標準アルゴリズム確立ja
jpcoar.awardTitle網羅的なHLA及び臨床情報の機械学習による同種移植の国際標準予後予測アルゴリズムja
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