ダウンロード数: 79
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.etap.2021.103726.pdf | 729.96 kB | Adobe PDF | 見る/開く |
タイトル: | Di-(2-ethylhexyl) phthalate enhances cytokine release from group 2 innate lymphoid cells in the presence of interleukin-33 |
著者: | Honda, Akiko https://orcid.org/0000-0002-7358-4372 (unconfirmed) Nagao, Megumi Tanaka, Michitaka Zaoshi, Wang Takano, Hirohisa https://orcid.org/0000-0002-3748-6206 (unconfirmed) |
著者名の別形: | 本田, 晶子 長尾, 慧 田中, 満祟 高野, 裕久 |
キーワード: | DEHP ILC2 Innate immune system Allergy |
発行日: | Oct-2021 |
出版者: | Elsevier BV |
誌名: | Environmental Toxicology and Pharmacology |
巻: | 87 |
論文番号: | 103726 |
抄録: | Epidemiological and experimental studies have shown that di-(2-ethylhexyl) phthalate (DEHP), a plasticizer, can aggravate allergic diseases. DEHP promotes adaptive immune responses, although its effect on the innate immune system remains largely unknown. The present study investigated the effects of DEHP on group 2 innate lymphoid cells (ILC2) that produce Th2 cytokines in response to epithelial cell-derived cytokines, such as interleukin (IL)-33. ILC2 (lineage-negative, CD45.2⁺, Sca1⁺, KLRG1⁺) were isolated from the lungs of C57BL/6 J mice. Co-exposure to DEHP and IL-33 significantly increased IL-5 release from ILC2, whose level was higher than that of the vehicle and IL-33 alone. The effects of DEHP in the presence of IL-33 showed an inverted-U dose-response. The present is the first report showing that DEHP exacerbates allergy through the innate immune system. |
著作権等: | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. The full-text file will be made open to the public on 1 October 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/267220 |
DOI(出版社版): | 10.1016/j.etap.2021.103726 |
PubMed ID: | 34418532 |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス