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Title: Analysis of factors associated with patient-reported physical functioning scores at discharge of allogeneic hematopoietic stem cell transplantation patients: a cross-sectional study
Authors: Murao, Masanobu
Hamada, Ryota
Kondo, Tadakazu
Miyasaka, Junsuke
Yoshida, Michiko
Yonezawa, Honami
Arai, Yasuyuki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9662-5093 (unconfirmed)
Kanda, Junya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-6704-3633 (unconfirmed)
Nankaku, Manabu
Ikeguchi, Ryosuke  kyouindb  KAKEN_id
Takaori-Kondo, Akifumi
Matsuda, Shuichi  kyouindb  KAKEN_id
Author's alias: 村尾, 昌信
濱田, 涼太
近藤, 忠一
宮坂, 淳介
吉田, 路子
米澤, 穂波
新井, 康之
諫田, 淳也
南角, 学
池口, 良輔
髙折, 晃史
松田, 秀一
Keywords: Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Quality of life (QOL)
The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)
Physical functioning domain
Exercise tolerance
Acute graft-versus-host disease (acute-GVHD)
Issue Date: Dec-2021
Publisher: Springer Nature
Journal title: Supportive Care in Cancer
Volume: 29
Issue: 12
Start page: 7569
End page: 7576
Abstract: Purpose: The purpose of this study was to clarify the independent factors related to patient-reported physical functioning (PF) scores at discharge of patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: A total of 103 patients who underwent allo-HSCT were included in this cross-sectional study. As a screening method, a single regression analysis was conducted with the PF domain in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at discharge as the dependent variable, and body mass index, adverse events related to HSCT, and objective physical functions as independent variables. Multiple regression analysis was performed with PF as the dependent variable and variables that passed the screening by single regression analysis and confounders as independent variables. Results: The mean PF score at discharge of the patients was 76.5 (standard deviation: 15.2). Based on the results of screening by the single regression analysis, length of stay, infections (+/−), acute graft-versus-host disease grade, brief fatigue inventory score (BFI), knee extensor strength, and 6-min walk distance (6MWD) were included in the multiple regression analysis. BFI (B = − 11.94, p < 0.001) and 6MWD (per 10 m) (B = 0.56, p = 0.001) were extracted as significant independent variables governing the PF at discharge in the multiple regression model (adjusted R2 = 0.59). Conclusion: Higher exercise tolerance and lower fatigue in patients who underwent allo-HSCT were associated independently with patient-reported better PF scores at discharge.
Rights: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00520-021-06323-5
The full-text file will be made open to the public on 12 June 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/268293
DOI(Published Version): 10.1007/s00520-021-06323-5
PubMed ID: 34120260
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