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j.stemcr.2021.03.021.pdf | 8.86 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Nakamura, Tomonori | en |
dc.contributor.author | Fujiwara, Kohei | en |
dc.contributor.author | Saitou, Mitinori | en |
dc.contributor.author | Tsukiyama, Tomoyuki | en |
dc.contributor.alternative | 中村, 友紀 | ja |
dc.contributor.alternative | 藤原, 浩平 | ja |
dc.contributor.alternative | 斎藤, 通紀 | ja |
dc.contributor.alternative | 築山, 智之 | ja |
dc.date.accessioned | 2022-08-02T00:44:23Z | - |
dc.date.available | 2022-08-02T00:44:23Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.uri | http://hdl.handle.net/2433/275696 | - |
dc.description.abstract | Human development has been studied for over a century, but the molecular mechanisms underlying human embryogenesis remain largely unknown due to technical difficulties and ethical issues. Accordingly, mice have been used as a model for mammalian development and studied extensively to infer human biology based on the conservation of fundamental processes between the two species. As research has progressed, however, species-specific differences in characteristics between rodents and primates have become apparent. Non-human primates (NHPs) have also been used for biomedical research, and are now attracting attention as a model for human development. Here, we summarize primate species from the evolutionary and genomic points of view. Then we review the current issues and progress in gene modification technology for NHPs. Finally, we discuss recent studies on the early embryogenesis of primates and future perspectives. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2021 The Authors. | en |
dc.rights | This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | non-human primates | en |
dc.subject | development | en |
dc.subject | gene modification with NHPs | en |
dc.subject | peri-implantation | en |
dc.subject | embryogenesis | en |
dc.title | Non-human primates as a model for human development | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Stem Cell Reports | en |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1093 | - |
dc.identifier.epage | 1103 | - |
dc.relation.doi | 10.1016/j.stemcr.2021.03.021 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 33979596 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 20K21370 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21370/ | - |
dc.identifier.eissn | 2213-6711 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 内在性相同組換え機構を利用した革新的ノックイン技術の開発 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス