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ファイル | 記述 | サイズ | フォーマット | |
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j.stemcr.2021.03.021.pdf | 8.86 MB | Adobe PDF | 見る/開く |
タイトル: | Non-human primates as a model for human development |
著者: | Nakamura, Tomonori https://orcid.org/0000-0002-0173-0780 (unconfirmed) Fujiwara, Kohei Saitou, Mitinori Tsukiyama, Tomoyuki |
著者名の別形: | 中村, 友紀 藤原, 浩平 斎藤, 通紀 築山, 智之 |
キーワード: | non-human primates development gene modification with NHPs peri-implantation embryogenesis |
発行日: | May-2021 |
出版者: | Elsevier BV |
誌名: | Stem Cell Reports |
巻: | 16 |
号: | 5 |
開始ページ: | 1093 |
終了ページ: | 1103 |
抄録: | Human development has been studied for over a century, but the molecular mechanisms underlying human embryogenesis remain largely unknown due to technical difficulties and ethical issues. Accordingly, mice have been used as a model for mammalian development and studied extensively to infer human biology based on the conservation of fundamental processes between the two species. As research has progressed, however, species-specific differences in characteristics between rodents and primates have become apparent. Non-human primates (NHPs) have also been used for biomedical research, and are now attracting attention as a model for human development. Here, we summarize primate species from the evolutionary and genomic points of view. Then we review the current issues and progress in gene modification technology for NHPs. Finally, we discuss recent studies on the early embryogenesis of primates and future perspectives. |
著作権等: | © 2021 The Authors. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. |
URI: | http://hdl.handle.net/2433/275696 |
DOI(出版社版): | 10.1016/j.stemcr.2021.03.021 |
PubMed ID: | 33979596 |
出現コレクション: | 学術雑誌掲載論文等 |
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