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ファイル | 記述 | サイズ | フォーマット | |
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68_7_217.pdf | 1.49 MB | Adobe PDF | 見る/開く |
タイトル: | 去勢抵抗性前立腺癌に対するカバジタキセル療法の治療成績とサルコペニアとの関連についての検討 |
その他のタイトル: | The Relationship between Sarcopenia and Survival after Cabazitaxel Treatment for Castration-Resistant Prostate Cancer |
著者: | 大西, 健太 田中, 宣道 堀, 俊太 中井, 靖 三宅, 牧人 穴井, 智 藤本, 清秀 |
著者名の別形: | ONISHI, Kenta TANAKA, Nobumichi HORI, Shunta NAKAI, Yasushi MIYAKE, Makito ANAI, Satoshi FUJIMOTO, Kiyohide |
キーワード: | Castration-resistant prostate cancer Cabazitaxel Sarcopenia |
発行日: | 31-Jul-2022 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 68 |
号: | 7 |
開始ページ: | 217 |
終了ページ: | 225 |
抄録: | Sarcopenia is a known predictor of overall survival in several diseases. We investigated the relationship between sarcopenia and outcome of treatment with cabazitaxel (CBZ) for castration-resistant prostate cancer (CRPC) by a retrospective analysis of 37 patients, who were given cabazitaxel at our hospital, from December 2014 to November 2020. The skeletal muscle mass was evaluated using the Psoas Muscle Mass Index (PMI: psoas major muscle area at the level of the third lumber vertebra (cm²)/height x height (m²)) through computed tomography images. The severe sarcopenia group (PMI<4.96) showed lower levels of serum albumin, in comparison with the non-severe sarcopenia group (PMI≥4.96). Multivariate analysis identified PMI (odds ratio=3.7; P=0.023) as an independent factor associated with prostate specific antigen response to CBZ therapy. However, there was no significant difference in the overall survival between the severe and the non-severe sarcopenia groups (P=0.1). Skeletal muscle mass might be closely correlated to the therapeutic response to CBZ, but not to the prognosis of patients with CRPC. Nutritional rehabilitation and exercises targeting sarcopenia for patients with prostate cancer should be considered. |
記述: | 本論文の要旨は,第109回日本泌尿器科学会総会で発表を行った. |
著作権等: | 許諾条件により本文は2023/08/01に公開 |
DOI: | 10.14989/ActaUrolJap_68_7_217 |
URI: | http://hdl.handle.net/2433/275779 |
PubMed ID: | 35924704 |
出現コレクション: | Vol.68 No.7 |
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