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dc.contributor.author | Namkoong, Ho | en |
dc.contributor.author | Edahiro, Ryuya | en |
dc.contributor.author | Takano, Tomomi | en |
dc.contributor.author | Nishihara, Hiroshi | en |
dc.contributor.author | Shirai, Yuya | en |
dc.contributor.author | Sonehara, Kyuto | en |
dc.contributor.author | Tanaka, Hiromu | en |
dc.contributor.author | Azekawa, Shuhei | en |
dc.contributor.author | Mikami, Yohei | en |
dc.contributor.author | Lee, Ho | en |
dc.contributor.author | Hasegawa, Takanori | en |
dc.contributor.author | Okudela, Koji | en |
dc.contributor.author | Okuzaki, Daisuke | en |
dc.contributor.author | Motooka, Daisuke | en |
dc.contributor.author | Kanai, Masahiro | en |
dc.contributor.author | Naito, Tatsuhiko | en |
dc.contributor.author | Yamamoto, Kenichi | en |
dc.contributor.author | Wang, Qingbo S. | en |
dc.contributor.author | Saiki, Ryunosuke | en |
dc.contributor.author | Ishihara, Rino | en |
dc.contributor.author | Matsubara, Yuta | en |
dc.contributor.author | Hamamoto, Junko | en |
dc.contributor.author | Hayashi, Hiroyuki | en |
dc.contributor.author | Yoshimura, Yukihiro | en |
dc.contributor.author | Tachikawa, Natsuo | en |
dc.contributor.author | Yanagita, Emmy | en |
dc.contributor.author | Hyugaji, Takayoshi | en |
dc.contributor.author | Shimizu, Eigo | en |
dc.contributor.author | Katayama, Kotoe | en |
dc.contributor.author | Kato, Yasuhiro | en |
dc.contributor.author | Morita, Takayoshi | en |
dc.contributor.author | Takahashi, Kazuhisa | en |
dc.contributor.author | Harada, Norihiro | en |
dc.contributor.author | Naito, Toshio | en |
dc.contributor.author | Hiki, Makoto | en |
dc.contributor.author | Matsushita, Yasushi | en |
dc.contributor.author | Takagi, Haruhi | en |
dc.contributor.author | Aoki, Ryousuke | en |
dc.contributor.author | Nakamura, Ai | en |
dc.contributor.author | Harada, Sonoko | en |
dc.contributor.author | Sasano, Hitoshi | en |
dc.contributor.author | Kabata, Hiroki | en |
dc.contributor.author | Masaki, Katsunori | en |
dc.contributor.author | Kamata, Hirofumi | en |
dc.contributor.author | Ikemura, Shinnosuke | en |
dc.contributor.author | Chubachi, Shotaro | en |
dc.contributor.author | Okamori, Satoshi | en |
dc.contributor.author | Terai, Hideki | en |
dc.contributor.author | Morita, Atsuho | en |
dc.contributor.author | Asakura, Takanori | en |
dc.contributor.author | Sasaki, Junichi | en |
dc.contributor.author | Morisaki, Hiroshi | en |
dc.contributor.author | Uwamino, Yoshifumi | en |
dc.contributor.author | Nanki, Kosaku | en |
dc.contributor.author | Uchida, Sho | en |
dc.contributor.author | Uno, Shunsuke | en |
dc.contributor.author | Nishimura, Tomoyasu | en |
dc.contributor.author | Ishiguro, Takashi | en |
dc.contributor.author | Isono, Taisuke | en |
dc.contributor.author | Shibata, Shun | en |
dc.contributor.author | Matsui, Yuma | en |
dc.contributor.author | Hosoda, Chiaki | en |
dc.contributor.author | Takano, Kenji | en |
dc.contributor.author | Nishida, Takashi | en |
dc.contributor.author | Kobayashi, Yoichi | en |
dc.contributor.author | Takaku, Yotaro | en |
dc.contributor.author | Takayanagi, Noboru | en |
dc.contributor.author | Ueda, Soichiro | en |
dc.contributor.author | Tada, Ai | en |
dc.contributor.author | Miyawaki, Masayoshi | en |
dc.contributor.author | Yamamoto, Masaomi | en |
dc.contributor.author | Yoshida, Eriko | en |
dc.contributor.author | Hayashi, Reina | en |
dc.contributor.author | Nagasaka, Tomoki | en |
dc.contributor.author | Arai, Sawako | en |
dc.contributor.author | Kaneko, Yutaro | en |
dc.contributor.author | Sasaki, Kana | en |
dc.contributor.author | Tagaya, Etsuko | en |
dc.contributor.author | Kawana, Masatoshi | en |
dc.contributor.author | Arimura, Ken | en |
dc.contributor.author | Takahashi, Kunihiko | en |
dc.contributor.author | Anzai, Tatsuhiko | en |
dc.contributor.author | Ito, Satoshi | en |
dc.contributor.author | Endo, Akifumi | en |
dc.contributor.author | Uchimura, Yuji | en |
dc.contributor.author | Miyazaki, Yasunari | en |
dc.contributor.author | Honda, Takayuki | en |
dc.contributor.author | Tateishi, Tomoya | en |
dc.contributor.author | Tohda, Shuji | en |
dc.contributor.author | Ichimura, Naoya | en |
dc.contributor.author | Sonobe, Kazunari | en |
dc.contributor.author | Sassa, Chihiro Tani | en |
dc.contributor.author | Nakajima, Jun | en |
dc.contributor.author | Nakano, Yasushi | en |
dc.contributor.author | Nakajima, Yukiko | en |
dc.contributor.author | Anan, Ryusuke | en |
dc.contributor.author | Arai, Ryosuke | en |
dc.contributor.author | Kurihara, Yuko | en |
dc.contributor.author | Harada, Yuko | en |
dc.contributor.author | Nishio, Kazumi | en |
dc.contributor.author | Ueda, Tetsuya | en |
dc.contributor.author | Azuma, Masanori | en |
dc.contributor.author | Saito, Ryuichi | en |
dc.contributor.author | Sado, Toshikatsu | en |
dc.contributor.author | Miyazaki, Yoshimune | en |
dc.contributor.author | Sato, Ryuichi | en |
dc.contributor.author | Haruta, Yuki | en |
dc.contributor.author | Nagasaki, Tadao | en |
dc.contributor.author | Yasui, Yoshinori | en |
dc.contributor.author | Hasegawa, Yoshinori | en |
dc.contributor.author | Mutoh, Yoshikazu | en |
dc.contributor.author | Kimura, Tomoki | en |
dc.contributor.author | Sato, Tomonori | en |
dc.contributor.author | Takei, Reoto | en |
dc.contributor.author | Hagimoto, Satoshi | en |
dc.contributor.author | Noguchi, Yoichiro | en |
dc.contributor.author | Yamano, Yasuhiko | en |
dc.contributor.author | Sasano, Hajime | en |
dc.contributor.author | Ota, Sho | en |
dc.contributor.author | Nakamori, Yasushi | en |
dc.contributor.author | Yoshiya, Kazuhisa | en |
dc.contributor.author | Saito, Fukuki | en |
dc.contributor.author | Yoshihara, Tomoyuki | en |
dc.contributor.author | Wada, Daiki | en |
dc.contributor.author | Iwamura, Hiromu | en |
dc.contributor.author | Kanayama, Syuji | en |
dc.contributor.author | Maruyama, Shuhei | en |
dc.contributor.author | Yoshiyama, Takashi | en |
dc.contributor.author | Ohta, Ken | en |
dc.contributor.author | Kokuto, Hiroyuki | en |
dc.contributor.author | Ogata, Hideo | en |
dc.contributor.author | Tanaka, Yoshiaki | en |
dc.contributor.author | Arakawa, Kenichi | en |
dc.contributor.author | Shimoda, Masafumi | en |
dc.contributor.author | Osawa, Takeshi | en |
dc.contributor.author | Tateno, Hiroki | en |
dc.contributor.author | Hase, Isano | en |
dc.contributor.author | Yoshida, Shuichi | en |
dc.contributor.author | Suzuki, Shoji | en |
dc.contributor.author | Kawada, Miki | en |
dc.contributor.author | Horinouchi, Hirohisa | en |
dc.contributor.author | Saito, Fumitake | en |
dc.contributor.author | Mitamura, Keiko | en |
dc.contributor.author | Hagihara, Masao | en |
dc.contributor.author | Ochi, Junichi | en |
dc.contributor.author | Uchida, Tomoyuki | en |
dc.contributor.author | Baba, Rie | en |
dc.contributor.author | Arai, Daisuke | en |
dc.contributor.author | Ogura, Takayuki | en |
dc.contributor.author | Takahashi, Hidenori | en |
dc.contributor.author | Hagiwara, Shigehiro | en |
dc.contributor.author | Nagao, Genta | en |
dc.contributor.author | Konishi, Shunichiro | en |
dc.contributor.author | Nakachi, Ichiro | en |
dc.contributor.author | Murakami, Koji | en |
dc.contributor.author | Yamada, Mitsuhiro | en |
dc.contributor.author | Sugiura, Hisatoshi | en |
dc.contributor.author | Sano, Hirohito | en |
dc.contributor.author | Matsumoto, Shuichiro | en |
dc.contributor.author | Kimura, Nozomu | en |
dc.contributor.author | Ono, Yoshinao | en |
dc.contributor.author | Baba, Hiroaki | en |
dc.contributor.author | Suzuki, Yusuke | en |
dc.contributor.author | Nakayama, Sohei | en |
dc.contributor.author | Masuzawa, Keita | en |
dc.contributor.author | Namba, Shinichi | en |
dc.contributor.author | Suzuki, Ken | en |
dc.contributor.author | Naito, Yoko | en |
dc.contributor.author | Liu, Yu-Chen | en |
dc.contributor.author | Takuwa, Ayako | en |
dc.contributor.author | Sugihara, Fuminori | en |
dc.contributor.author | Wing, James B. | en |
dc.contributor.author | Sakakibara, Shuhei | en |
dc.contributor.author | Hizawa, Nobuyuki | en |
dc.contributor.author | Shiroyama, Takayuki | en |
dc.contributor.author | Miyawaki, Satoru | en |
dc.contributor.author | Kawamura, Yusuke | en |
dc.contributor.author | Nakayama, Akiyoshi | en |
dc.contributor.author | Matsuo, Hirotaka | en |
dc.contributor.author | Maeda, Yuichi | en |
dc.contributor.author | Nii, Takuro | en |
dc.contributor.author | Noda, Yoshimi | en |
dc.contributor.author | Niitsu, Takayuki | en |
dc.contributor.author | Adachi, Yuichi | en |
dc.contributor.author | Enomoto, Takatoshi | en |
dc.contributor.author | Amiya, Saori | en |
dc.contributor.author | Hara, Reina | en |
dc.contributor.author | Yamaguchi, Yuta | en |
dc.contributor.author | Murakami, Teruaki | en |
dc.contributor.author | Kuge, Tomoki | en |
dc.contributor.author | Matsumoto, Kinnosuke | en |
dc.contributor.author | Yamamoto, Yuji | en |
dc.contributor.author | Yamamoto, Makoto | en |
dc.contributor.author | Yoneda, Midori | en |
dc.contributor.author | Kishikawa, Toshihiro | en |
dc.contributor.author | Yamada, Shuhei | en |
dc.contributor.author | Kawabata, Shuhei | en |
dc.contributor.author | Kijima, Noriyuki | en |
dc.contributor.author | Takagaki, Masatoshi | en |
dc.contributor.author | Sasa, Noah | en |
dc.contributor.author | Ueno, Yuya | en |
dc.contributor.author | Suzuki, Motoyuki | en |
dc.contributor.author | Takemoto, Norihiko | en |
dc.contributor.author | Eguchi, Hirotaka | en |
dc.contributor.author | Fukusumi, Takahito | en |
dc.contributor.author | Imai, Takao | en |
dc.contributor.author | Fukushima, Munehisa | en |
dc.contributor.author | Kishima, Haruhiko | en |
dc.contributor.author | Inohara, Hidenori | en |
dc.contributor.author | Tomono, Kazunori | en |
dc.contributor.author | Kato, Kazuto | en |
dc.contributor.author | Takahashi, Meiko | en |
dc.contributor.author | Matsuda, Fumihiko | en |
dc.contributor.author | Hirata, Haruhiko | en |
dc.contributor.author | Takeda, Yoshito | en |
dc.contributor.author | Koh, Hidefumi | en |
dc.contributor.author | Manabe, Tadashi | en |
dc.contributor.author | Funatsu, Yohei | en |
dc.contributor.author | Ito, Fumimaro | en |
dc.contributor.author | Fukui, Takahiro | en |
dc.contributor.author | Shinozuka, Keisuke | en |
dc.contributor.author | Kohashi, Sumiko | en |
dc.contributor.author | Miyazaki, Masatoshi | en |
dc.contributor.author | Shoko, Tomohisa | en |
dc.contributor.author | Kojima, Mitsuaki | en |
dc.contributor.author | Adachi, Tomohiro | en |
dc.contributor.author | Ishikawa, Motonao | en |
dc.contributor.author | Takahashi, Kenichiro | en |
dc.contributor.author | Inoue, Takashi | en |
dc.contributor.author | Hirano, Toshiyuki | en |
dc.contributor.author | Kobayashi, Keigo | en |
dc.contributor.author | Takaoka, Hatsuyo | en |
dc.contributor.author | Watanabe, Kazuyoshi | en |
dc.contributor.author | Miyazawa, Naoki | en |
dc.contributor.author | Kimura, Yasuhiro | en |
dc.contributor.author | Sado, Reiko | en |
dc.contributor.author | Sugimoto, Hideyasu | en |
dc.contributor.author | Kamiya, Akane | en |
dc.contributor.author | Kuwahara, Naota | en |
dc.contributor.author | Fujiwara, Akiko | en |
dc.contributor.author | Matsunaga, Tomohiro | en |
dc.contributor.author | Sato, Yoko | en |
dc.contributor.author | Okada, Takenori | en |
dc.contributor.author | Hirai, Yoshihiro | en |
dc.contributor.author | Kawashima, Hidetoshi | en |
dc.contributor.author | Narita, Atsuya | en |
dc.contributor.author | Niwa, Kazuki | en |
dc.contributor.author | Sekikawa, Yoshiyuki | en |
dc.contributor.author | Nishi, Koichi | en |
dc.contributor.author | Nishitsuji, Masaru | en |
dc.contributor.author | Tani, Mayuko | en |
dc.contributor.author | Suzuki, Junya | en |
dc.contributor.author | Nakatsumi, Hiroki | en |
dc.contributor.author | Ogura, Takashi | en |
dc.contributor.author | Kitamura, Hideya | en |
dc.contributor.author | Hagiwara, Eri | en |
dc.contributor.author | Murohashi, Kota | en |
dc.contributor.author | Okabayashi, Hiroko | en |
dc.contributor.author | Mochimaru, Takao | en |
dc.contributor.author | Nukaga, Shigenari | en |
dc.contributor.author | Satomi, Ryosuke | en |
dc.contributor.author | Oyamada, Yoshitaka | en |
dc.contributor.author | Mori, Nobuaki | en |
dc.contributor.author | Baba, Tomoya | en |
dc.contributor.author | Fukui, Yasutaka | en |
dc.contributor.author | Odate, Mitsuru | en |
dc.contributor.author | Mashimo, Shuko | en |
dc.contributor.author | Makino, Yasushi | en |
dc.contributor.author | Yagi, Kazuma | en |
dc.contributor.author | Hashiguchi, Mizuha | en |
dc.contributor.author | Kagyo, Junko | en |
dc.contributor.author | Shiomi, Tetsuya | en |
dc.contributor.author | Fuke, Satoshi | en |
dc.contributor.author | Saito, Hiroshi | en |
dc.contributor.author | Tsuchida, Tomoya | en |
dc.contributor.author | Fujitani, Shigeki | en |
dc.contributor.author | Takita, Mumon | en |
dc.contributor.author | Morikawa, Daiki | en |
dc.contributor.author | Yoshida, Toru | en |
dc.contributor.author | Izumo, Takehiro | en |
dc.contributor.author | Inomata, Minoru | en |
dc.contributor.author | Kuse, Naoyuki | en |
dc.contributor.author | Awano, Nobuyasu | en |
dc.contributor.author | Tone, Mari | en |
dc.contributor.author | Ito, Akihiro | en |
dc.contributor.author | Nakamura, Yoshihiko | en |
dc.contributor.author | Hoshino, Kota | en |
dc.contributor.author | Maruyama, Junichi | en |
dc.contributor.author | Ishikura, Hiroyasu | en |
dc.contributor.author | Takata, Tohru | en |
dc.contributor.author | Odani, Toshio | en |
dc.contributor.author | Amishima, Masaru | en |
dc.contributor.author | Hattori, Takeshi | en |
dc.contributor.author | Shichinohe, Yasuo | en |
dc.contributor.author | Kagaya, Takashi | en |
dc.contributor.author | Kita, Toshiyuki | en |
dc.contributor.author | Ohta, Kazuhide | en |
dc.contributor.author | Sakagami, Satoru | en |
dc.contributor.author | Koshida, Kiyoshi | en |
dc.contributor.author | Hayashi, Kentaro | en |
dc.contributor.author | Shimizu, Tetsuo | en |
dc.contributor.author | Kozu, Yutaka | en |
dc.contributor.author | Hiranuma, Hisato | en |
dc.contributor.author | Gon, Yasuhiro | en |
dc.contributor.author | Izumi, Namiki | en |
dc.contributor.author | Nagata, Kaoru | en |
dc.contributor.author | Ueda, Ken | en |
dc.contributor.author | Taki, Reiko | en |
dc.contributor.author | Hanada, Satoko | en |
dc.contributor.author | Kawamura, Kodai | en |
dc.contributor.author | Ichikado, Kazuya | en |
dc.contributor.author | Nishiyama, Kenta | en |
dc.contributor.author | Muranaka, Hiroyuki | en |
dc.contributor.author | Nakamura, Kazunori | en |
dc.contributor.author | Hashimoto, Naozumi | en |
dc.contributor.author | Wakahara, Keiko | en |
dc.contributor.author | Koji, Sakamoto | en |
dc.contributor.author | Omote, Norihito | en |
dc.contributor.author | Ando, Akira | en |
dc.contributor.author | Kodama, Nobuhiro | en |
dc.contributor.author | Kaneyama, Yasunari | en |
dc.contributor.author | Maeda, Shunsuke | en |
dc.contributor.author | Kuraki, Takashige | en |
dc.contributor.author | Matsumoto, Takemasa | en |
dc.contributor.author | Yokote, Koutaro | en |
dc.contributor.author | Nakada, Taka-Aki | en |
dc.contributor.author | Abe, Ryuzo | en |
dc.contributor.author | Oshima, Taku | en |
dc.contributor.author | Shimada, Tadanaga | en |
dc.contributor.author | Harada, Masahiro | en |
dc.contributor.author | Takahashi, Takeshi | en |
dc.contributor.author | Ono, Hiroshi | en |
dc.contributor.author | Sakurai, Toshihiro | en |
dc.contributor.author | Shibusawa, Takayuki | en |
dc.contributor.author | Kimizuka, Yoshifumi | en |
dc.contributor.author | Kawana, Akihiko | en |
dc.contributor.author | Sano, Tomoya | en |
dc.contributor.author | Watanabe, Chie | en |
dc.contributor.author | Suematsu, Ryohei | en |
dc.contributor.author | Sageshima, Hisako | en |
dc.contributor.author | Yoshifuji, Ayumi | en |
dc.contributor.author | Ito, Kazuto | en |
dc.contributor.author | Takahashi, Saeko | en |
dc.contributor.author | Ishioka, Kota | en |
dc.contributor.author | Nakamura, Morio | en |
dc.contributor.author | Masuda, Makoto | en |
dc.contributor.author | Wakabayashi, Aya | en |
dc.contributor.author | Watanabe, Hiroki | en |
dc.contributor.author | Ueda, Suguru | en |
dc.contributor.author | Nishikawa, Masanori | en |
dc.contributor.author | Chihara, Yusuke | en |
dc.contributor.author | Takeuchi, Mayumi | en |
dc.contributor.author | Onoi, Keisuke | en |
dc.contributor.author | Shinozuka, Jun | en |
dc.contributor.author | Sueyoshi, Atsushi | en |
dc.contributor.author | Nagasaki, Yoji | en |
dc.contributor.author | Okamoto, Masaki | en |
dc.contributor.author | Ishihara, Sayoko | en |
dc.contributor.author | Shimo, Masatoshi | en |
dc.contributor.author | Tokunaga, Yoshihisa | en |
dc.contributor.author | Kusaka, Yu | en |
dc.contributor.author | Ohba, Takehiko | en |
dc.contributor.author | Isogai, Susumu | en |
dc.contributor.author | Ogawa, Aki | en |
dc.contributor.author | Inoue, Takuya | en |
dc.contributor.author | Fukuyama, Satoru | en |
dc.contributor.author | Eriguchi, Yoshihiro | en |
dc.contributor.author | Yonekawa, Akiko | en |
dc.contributor.author | Kan-o, Keiko | en |
dc.contributor.author | Matsumoto, Koichiro | en |
dc.contributor.author | Kanaoka, Kensuke | en |
dc.contributor.author | Ihara, Shoichi | en |
dc.contributor.author | Komuta, Kiyoshi | en |
dc.contributor.author | Inoue, Yoshiaki | en |
dc.contributor.author | Chiba, Shigeru | en |
dc.contributor.author | Yamagata, Kunihiro | en |
dc.contributor.author | Hiramatsu, Yuji | en |
dc.contributor.author | Kai, Hirayasu | en |
dc.contributor.author | Asano, Koichiro | en |
dc.contributor.author | Oguma, Tsuyoshi | en |
dc.contributor.author | Ito, Yoko | en |
dc.contributor.author | Hashimoto, Satoru | en |
dc.contributor.author | Yamasaki, Masaki | en |
dc.contributor.author | Kasamatsu, Yu | en |
dc.contributor.author | Komase, Yuko | en |
dc.contributor.author | Hida, Naoya | en |
dc.contributor.author | Tsuburai, Takahiro | en |
dc.contributor.author | Oyama, Baku | en |
dc.contributor.author | Takada, Minoru | en |
dc.contributor.author | Kanda, Hidenori | en |
dc.contributor.author | Kitagawa, Yuichiro | en |
dc.contributor.author | Fukuta, Tetsuya | en |
dc.contributor.author | Miyake, Takahito | en |
dc.contributor.author | Yoshida, Shozo | en |
dc.contributor.author | Ogura, Shinji | en |
dc.contributor.author | Abe, Shinji | en |
dc.contributor.author | Kono, Yuta | en |
dc.contributor.author | Togashi, Yuki | en |
dc.contributor.author | Takoi, Hiroyuki | en |
dc.contributor.author | Kikuchi, Ryota | en |
dc.contributor.author | Ogawa, Shinichi | en |
dc.contributor.author | Ogata, Tomouki | en |
dc.contributor.author | Ishihara, Shoichiro | en |
dc.contributor.author | Kanehiro, Arihiko | en |
dc.contributor.author | Ozaki, Shinji | en |
dc.contributor.author | Fuchimoto, Yasuko | en |
dc.contributor.author | Wada, Sae | en |
dc.contributor.author | Fujimoto, Nobukazu | en |
dc.contributor.author | Nishiyama, Kei | en |
dc.contributor.author | Terashima, Mariko | en |
dc.contributor.author | Beppu, Satoru | en |
dc.contributor.author | Yoshida, Kosuke | en |
dc.contributor.author | Narumoto, Osamu | en |
dc.contributor.author | Nagai, Hideaki | en |
dc.contributor.author | Ooshima, Nobuharu | en |
dc.contributor.author | Motegi, Mitsuru | en |
dc.contributor.author | Umeda, Akira | en |
dc.contributor.author | Miyagawa, Kazuya | en |
dc.contributor.author | Shimada, Hisato | en |
dc.contributor.author | Endo, Mayu | en |
dc.contributor.author | Ohira, Yoshiyuki | en |
dc.contributor.author | Watanabe, Masafumi | en |
dc.contributor.author | Inoue, Sumito | en |
dc.contributor.author | Igarashi, Akira | en |
dc.contributor.author | Sato, Masamichi | en |
dc.contributor.author | Sagara, Hironori | en |
dc.contributor.author | Tanaka, Akihiko | en |
dc.contributor.author | Ohta, Shin | en |
dc.contributor.author | Kimura, Tomoyuki | en |
dc.contributor.author | Shibata, Yoko | en |
dc.contributor.author | Tanino, Yoshinori | en |
dc.contributor.author | Nikaido, Takefumi | en |
dc.contributor.author | Minemura, Hiroyuki | en |
dc.contributor.author | Sato, Yuki | en |
dc.contributor.author | Yamada, Yuichiro | en |
dc.contributor.author | Hashino, Takuya | en |
dc.contributor.author | Shinoki, Masato | en |
dc.contributor.author | Iwagoe, Hajime | en |
dc.contributor.author | Takahashi, Hiroshi | en |
dc.contributor.author | Fujii, Kazuhiko | en |
dc.contributor.author | Kishi, Hiroto | en |
dc.contributor.author | Kanai, Masayuki | en |
dc.contributor.author | Imamura, Tomonori | en |
dc.contributor.author | Yamashita, Tatsuya | en |
dc.contributor.author | Yatomi, Masakiyo | en |
dc.contributor.author | Maeno, Toshitaka | en |
dc.contributor.author | Hayashi, Shinichi | en |
dc.contributor.author | Takahashi, Mai | en |
dc.contributor.author | Kuramochi, Mizuki | en |
dc.contributor.author | Kamimaki, Isamu | en |
dc.contributor.author | Tominaga, Yoshiteru | en |
dc.contributor.author | Ishii, Tomoo | en |
dc.contributor.author | Utsugi, Mitsuyoshi | en |
dc.contributor.author | Ono, Akihiro | en |
dc.contributor.author | Tanaka, Toru | en |
dc.contributor.author | Kashiwada, Takeru | en |
dc.contributor.author | Fujita, Kazue | en |
dc.contributor.author | Saito, Yoshinobu | en |
dc.contributor.author | Seike, Masahiro | en |
dc.contributor.author | Watanabe, Hiroko | en |
dc.contributor.author | Matsuse, Hiroto | en |
dc.contributor.author | Kodaka, Norio | en |
dc.contributor.author | Nakano, Chihiro | en |
dc.contributor.author | Oshio, Takeshi | en |
dc.contributor.author | Hirouchi, Takatomo | en |
dc.contributor.author | Makino, Shohei | en |
dc.contributor.author | Egi, Moritoki | en |
dc.contributor.author | Matsuda, Koichi | en |
dc.contributor.author | Yamanashi, Yuji | en |
dc.contributor.author | Furukawa, Yoichi | en |
dc.contributor.author | Morisaki, Takayuki | en |
dc.contributor.author | Murakami, Yoshinori | en |
dc.contributor.author | Kamatani, Yoichiro | en |
dc.contributor.author | Muto, Kaori | en |
dc.contributor.author | Nagai, Akiko | en |
dc.contributor.author | Obara, Wataru | en |
dc.contributor.author | Yamaji, Ken | en |
dc.contributor.author | Asai, Satoshi | en |
dc.contributor.author | Takahashi, Yasuo | en |
dc.contributor.author | Suzuki, Takao | en |
dc.contributor.author | Sinozaki, Nobuaki | en |
dc.contributor.author | Yamaguchi, Hiroki | en |
dc.contributor.author | Minami, Shiro | en |
dc.contributor.author | Murayama, Shigeo | en |
dc.contributor.author | Yoshimori, Kozo | en |
dc.contributor.author | Nagayama, Satoshi | en |
dc.contributor.author | Obata, Daisuke | en |
dc.contributor.author | Higashiyama, Masahiko | en |
dc.contributor.author | Masumoto, Akihide | en |
dc.contributor.author | Koretsune, Yukihiro | en |
dc.contributor.author | Omae, Yosuke | en |
dc.contributor.author | Nannya, Yasuhito | en |
dc.contributor.author | Ueno, Takafumi | en |
dc.contributor.author | Katayama, Kazuhiko | en |
dc.contributor.author | Ai, Masumi | en |
dc.contributor.author | Fukui, Yoshinori | en |
dc.contributor.author | Kumanogoh, Atsushi | en |
dc.contributor.author | Sato, Toshiro | en |
dc.contributor.author | Hasegawa, Naoki | en |
dc.contributor.author | Tokunaga, Katsushi | en |
dc.contributor.author | Ishii, Makoto | en |
dc.contributor.author | Koike, Ryuji | en |
dc.contributor.author | Kitagawa, Yuko | en |
dc.contributor.author | Kimura, Akinori | en |
dc.contributor.author | Imoto, Seiya | en |
dc.contributor.author | Miyano, Satoru | en |
dc.contributor.author | Ogawa, Seishi | en |
dc.contributor.author | Kanai, Takanori | en |
dc.contributor.author | Fukunaga, Koichi | en |
dc.contributor.author | Okada, Yukinori | en |
dc.contributor.alternative | 南宮, 湖 | ja |
dc.contributor.alternative | 枝廣, 龍哉 | ja |
dc.contributor.alternative | 高野, 友美 | ja |
dc.contributor.alternative | 西原, 広史 | ja |
dc.contributor.alternative | 佐伯, 龍之介 | ja |
dc.contributor.alternative | 高橋, めい子 | ja |
dc.contributor.alternative | 松田, 文彦 | ja |
dc.contributor.alternative | 南谷, 泰仁 | ja |
dc.contributor.alternative | 片山, 和彦 | ja |
dc.contributor.alternative | 藍, 真澄 | ja |
dc.contributor.alternative | 熊ノ郷, 淳 | ja |
dc.contributor.alternative | 佐藤, 俊朗 | ja |
dc.contributor.alternative | 長谷川, 直樹 | ja |
dc.contributor.alternative | 石井, 誠 | ja |
dc.contributor.alternative | 小池, 竜司 | ja |
dc.contributor.alternative | 北川, 雄光 | ja |
dc.contributor.alternative | 木村, 彰方 | ja |
dc.contributor.alternative | 井元, 清哉 | ja |
dc.contributor.alternative | 宮野, 悟 | ja |
dc.contributor.alternative | 小川, 誠司 | ja |
dc.contributor.alternative | 金井, 隆典 | ja |
dc.contributor.alternative | 福永, 興壱 | ja |
dc.contributor.alternative | 岡田, 随象 | ja |
dc.date.accessioned | 2022-09-22T00:11:37Z | - |
dc.date.available | 2022-09-22T00:11:37Z | - |
dc.date.issued | 2022-09-22 | - |
dc.identifier.uri | http://hdl.handle.net/2433/276335 | - |
dc.description | 「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10. | ja |
dc.description.abstract | Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2022 | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Genetics research | en |
dc.subject | Genome-wide association studies | en |
dc.subject | Immunogenetics | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | Viral infection | en |
dc.title | DOCK2 is involved in the host genetics and biology of severe COVID-19 | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature | en |
dc.identifier.volume | 609 | - |
dc.identifier.issue | 7928 | - |
dc.identifier.spage | 754 | - |
dc.identifier.epage | 760 | - |
dc.relation.doi | 10.1038/s41586-022-05163-5 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 35940203 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2022-08-10-3 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 22H00476 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00476/ | - |
dc.identifier.pissn | 0028-0836 | - |
dc.identifier.eissn | 1476-4687 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 統合シークエンス解析による免疫アレルギー疾患ダイナミクスの解明 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス