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2211-5463.13124.pdf | 1.31 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Tanikawa, Kana | en |
dc.contributor.author | Kaneko, Kentaro | en |
dc.contributor.author | Abe, Shimon | en |
dc.contributor.author | Nakato, Jyunya | en |
dc.contributor.author | Tokuyama, Yuki | en |
dc.contributor.author | Odaka, Sayano | en |
dc.contributor.author | Iwakura, Hiroshi | en |
dc.contributor.author | Sato, Masaru | en |
dc.contributor.author | Kurabayashi, Atsushi | en |
dc.contributor.author | Suzuki, Hideyuki | en |
dc.contributor.author | Makita, Miki | en |
dc.contributor.author | Ikemoto, Hiroyuki | en |
dc.contributor.author | Matsumura, Shigenobu | en |
dc.contributor.author | Inoue, Kazuo | en |
dc.contributor.author | Ohinata, Kousaku | en |
dc.contributor.alternative | 谷川, 加奈 | ja |
dc.contributor.alternative | 金子, 賢太朗 | ja |
dc.contributor.alternative | 阿部, 志門 | ja |
dc.contributor.alternative | 中戸, 絢也 | ja |
dc.contributor.alternative | 徳山, 雄基 | ja |
dc.contributor.alternative | 松村, 成暢 | ja |
dc.contributor.alternative | 井上, 和生 | ja |
dc.contributor.alternative | 大日向, 耕作 | ja |
dc.date.accessioned | 2022-10-03T07:03:06Z | - |
dc.date.available | 2022-10-03T07:03:06Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | http://hdl.handle.net/2433/276524 | - |
dc.description.abstract | Ghrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion. We observed that enzymatic digest of wheat gluten stimulated ghrelin secretion from mouse ghrelinoma 3-1, a ghrelin-releasing cell line. Further on, we characterized the ghrelin-releasing peptides present in the digest by comprehensive peptide analysis using liquid chromatography-mass spectrometry and structure-activity relationship. Among the candidate peptides, we found that SQQQQPVLPQQPSF, LSVTSPQQVSY and YPTSL stimulated ghrelin release. We then named them wheat-ghretropin A, B and C, respectively. In addition, we observed that wheat-ghretropin A increased plasma ghrelin concentration and food intake in mice after oral administration. Thus, we demonstrated that wheat-ghretropin stimulates ghrelin release both in vitro and in vivo. To the best of our knowledge, this is the first report of a wheat-derived exogenous bioactive peptide that stimulates ghrelin secretion. | en |
dc.language.iso | eng | - |
dc.publisher | Wiley | en |
dc.publisher | Federation of European Biochemical Societies | en |
dc.rights | © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. | en |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | comprehensive peptide analysis | en |
dc.subject | food intake | en |
dc.subject | ghrelin | en |
dc.subject | structure–activity relationship | en |
dc.subject | wheat peptide | en |
dc.title | Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | FEBS Open Bio | en |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1144 | - |
dc.identifier.epage | 1152 | - |
dc.relation.doi | 10.1002/2211-5463.13124 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 33605550 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2211-5463 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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