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dc.contributor.authorTanikawa, Kanaen
dc.contributor.authorKaneko, Kentaroen
dc.contributor.authorAbe, Shimonen
dc.contributor.authorNakato, Jyunyaen
dc.contributor.authorTokuyama, Yukien
dc.contributor.authorOdaka, Sayanoen
dc.contributor.authorIwakura, Hiroshien
dc.contributor.authorSato, Masaruen
dc.contributor.authorKurabayashi, Atsushien
dc.contributor.authorSuzuki, Hideyukien
dc.contributor.authorMakita, Mikien
dc.contributor.authorIkemoto, Hiroyukien
dc.contributor.authorMatsumura, Shigenobuen
dc.contributor.authorInoue, Kazuoen
dc.contributor.authorOhinata, Kousakuen
dc.contributor.alternative谷川, 加奈ja
dc.contributor.alternative金子, 賢太朗ja
dc.contributor.alternative阿部, 志門ja
dc.contributor.alternative中戸, 絢也ja
dc.contributor.alternative徳山, 雄基ja
dc.contributor.alternative松村, 成暢ja
dc.contributor.alternative井上, 和生ja
dc.contributor.alternative大日向, 耕作ja
dc.description.abstractGhrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion. We observed that enzymatic digest of wheat gluten stimulated ghrelin secretion from mouse ghrelinoma 3-1, a ghrelin-releasing cell line. Further on, we characterized the ghrelin-releasing peptides present in the digest by comprehensive peptide analysis using liquid chromatography-mass spectrometry and structure-activity relationship. Among the candidate peptides, we found that SQQQQPVLPQQPSF, LSVTSPQQVSY and YPTSL stimulated ghrelin release. We then named them wheat-ghretropin A, B and C, respectively. In addition, we observed that wheat-ghretropin A increased plasma ghrelin concentration and food intake in mice after oral administration. Thus, we demonstrated that wheat-ghretropin stimulates ghrelin release both in vitro and in vivo. To the best of our knowledge, this is the first report of a wheat-derived exogenous bioactive peptide that stimulates ghrelin secretion.en
dc.publisherFederation of European Biochemical Societiesen
dc.rights© 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.en
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectcomprehensive peptide analysisen
dc.subjectfood intakeen
dc.subjectstructure–activity relationshipen
dc.subjectwheat peptideen
dc.titleWheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat proteinen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleFEBS Open Bioen
dcterms.accessRightsopen access-
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