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Title: Wheat‐ghretropins: novel ghrelin‐releasing peptides derived from wheat protein
Authors: Tanikawa, Kana
Kaneko, Kentaro  KAKEN_id  orcid (unconfirmed)
Abe, Shimon
Nakato, Jyunya
Tokuyama, Yuki
Odaka, Sayano
Iwakura, Hiroshi
Sato, Masaru
Kurabayashi, Atsushi
Suzuki, Hideyuki
Makita, Miki
Ikemoto, Hiroyuki
Matsumura, Shigenobu
Inoue, Kazuo  kyouindb  KAKEN_id  orcid (unconfirmed)
Ohinata, Kousaku
Author's alias: 谷川, 加奈
金子, 賢太朗
阿部, 志門
中戸, 絢也
徳山, 雄基
松村, 成暢
井上, 和生
大日向, 耕作
Keywords: comprehensive peptide analysis
food intake
structure–activity relationship
wheat peptide
Issue Date: Apr-2021
Publisher: Wiley
Federation of European Biochemical Societies
Journal title: FEBS Open Bio
Volume: 11
Issue: 4
Start page: 1144
End page: 1152
Abstract: Ghrelin is an endogenous orexigenic hormone mainly produced by stomach cells and is reported to influence appetite, gastrointestinal motility and growth hormone secretion. We observed that enzymatic digest of wheat gluten stimulated ghrelin secretion from mouse ghrelinoma 3-1, a ghrelin-releasing cell line. Further on, we characterized the ghrelin-releasing peptides present in the digest by comprehensive peptide analysis using liquid chromatography-mass spectrometry and structure-activity relationship. Among the candidate peptides, we found that SQQQQPVLPQQPSF, LSVTSPQQVSY and YPTSL stimulated ghrelin release. We then named them wheat-ghretropin A, B and C, respectively. In addition, we observed that wheat-ghretropin A increased plasma ghrelin concentration and food intake in mice after oral administration. Thus, we demonstrated that wheat-ghretropin stimulates ghrelin release both in vitro and in vivo. To the best of our knowledge, this is the first report of a wheat-derived exogenous bioactive peptide that stimulates ghrelin secretion.
Rights: © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI(Published Version): 10.1002/2211-5463.13124
PubMed ID: 33605550
Appears in Collections:Journal Articles

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