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j.ultrasmedbio.2022.07.015.pdf | 1.76 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Xu, Shixuan | en |
dc.contributor.author | Ito, Akira | en |
dc.contributor.author | Wang, Tianshu | en |
dc.contributor.author | Kawai, Hideki | en |
dc.contributor.author | Aoyama, Tomoki | en |
dc.contributor.author | Kuroki, Hiroshi | en |
dc.contributor.alternative | 伊藤, 明良 | ja |
dc.contributor.alternative | 河合, 秀紀 | ja |
dc.contributor.alternative | 青山, 朋樹 | ja |
dc.contributor.alternative | 黒木, 裕士 | ja |
dc.date.accessioned | 2022-10-24T05:38:20Z | - |
dc.date.available | 2022-10-24T05:38:20Z | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.uri | http://hdl.handle.net/2433/276841 | - |
dc.description.abstract | The aim of this study was to verify the effects of ultrasound on dorsal root ganglion (DRG) neurons at the injury site in a rat model of sciatic nerve crush injury. We evaluated the mRNA expression of neurotrophic and pro-inflammatory factors by quantitative reverse transcription polymerase chain reaction 7 and 14 d post-injury. We also evaluated the protein levels of brain-derived neurotrophic factor (BDNF) 7 and 14 d post-injury. Axon regeneration and motor function analyses were performed 21 days after injury to confirm the facilitative effect of ultrasound on nerve regeneration. In the ultrasound group, BDNF and interleukin-6 mRNA expression of the DRG was significantly reduced 7 d post-injury. Compared with the sham group, the BDNF protein expression of the DRG in the ultrasound group remained at a higher level 14 d post-injury. Motor function, myelinated fiber density and myelin sheath thickness were significantly higher in the ultrasound group than in the sham group 21 d post-injury. These results indicate that ultrasound therapy at the injury site promotes nerve regeneration and modulates gene and protein expression in the DRG of a rat model of a sciatic nerve crush injury. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights | The full-text file will be made open to the public on 1 December 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Ultrasound therapy | en |
dc.subject | Dorsal root ganglion | en |
dc.subject | Peripheral nerve injury | en |
dc.subject | Neurotrophic factor | en |
dc.subject | Pro-inflammatory factor | en |
dc.subject | Nerve regeneration | en |
dc.subject | Gene expression | en |
dc.subject | Protein expression | en |
dc.subject | Motor function | en |
dc.title | Ultrasound Therapy of Injury Site Modulates Gene and Protein Expressions in the Dorsal Root Ganglion in a Sciatic Nerve Crush Injury Rat Model | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Ultrasound in Medicine & Biology | en |
dc.identifier.volume | 48 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 2502 | - |
dc.identifier.epage | 2511 | - |
dc.relation.doi | 10.1016/j.ultrasmedbio.2022.07.015 | - |
dc.textversion | author | - |
dc.identifier.pmid | 36180311 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2023-12-01 | - |
datacite.awardNumber | 18H03129 | - |
datacite.awardNumber | 21K19709 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18H03129/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21K19709/ | - |
dc.identifier.pissn | 0301-5629 | - |
dc.identifier.eissn | 1879-291X | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 移植再生医療リハビリテーションの開発 | ja |
jpcoar.awardTitle | 再生医療とリハビリテーションの融合によるニッチとセルラーのリハビリテーション開発 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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