ダウンロード数: 25
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
70_c21-00815.pdf | 8.15 MB | Adobe PDF | 見る/開く |
タイトル: | Elucidation of Complex Dynamic Intermolecular Interactions in Membranes |
著者: | Matsuzaki, Katsumi https://orcid.org/0000-0002-0182-1690 (unconfirmed) |
著者名の別形: | 松﨑, 勝巳 |
キーワード: | antimicrobial peptide amyloid β-protein transmembrane helix membrane protein peptide–lipid interaction |
発行日: | 1-Jan-2022 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Chemical and Pharmaceutical Bulletin |
巻: | 70 |
号: | 1 |
開始ページ: | 1 |
終了ページ: | 9 |
抄録: | Biomembranes composed of various proteins and lipids play important roles in cellular functions, such as signal transduction and substance transport. In addition, some bioactive peptides and pathogenic proteins target membrane proteins and lipids to exert their effects. Therefore, an understanding of dynamic and complex intermolecular interactions among these membrane constituents is needed to elucidate their mechanisms. This review summarizes the major research carried out in the author’s laboratory on how lipids and their inhomogeneous distributions regulate the structures and functions of antimicrobial peptides and Alzheimer’s amyloid β-protein. Also, how to detect transmembrane helix–helix and membrane protein–protein interactions and how they are modulated by lipids are discussed. |
著作権等: | © 2022 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/276874 |
DOI(出版社版): | 10.1248/cpb.c21-00815 |
PubMed ID: | 34980725 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。