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DCフィールド | 値 | 言語 |
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dc.contributor.author | Ohta, Kazushi | en |
dc.contributor.author | Hiraki, Shinobu | en |
dc.contributor.author | Miyanabe, Masakatsu | en |
dc.contributor.author | Ueki, Tatsuro | en |
dc.contributor.author | Manabe, Yuki | en |
dc.contributor.author | Sugawara, Tatsuya | en |
dc.contributor.alternative | 太田, 知志 | ja |
dc.contributor.alternative | 真鍋, 祐樹 | ja |
dc.contributor.alternative | 菅原, 達也 | ja |
dc.date.accessioned | 2022-11-16T02:07:38Z | - |
dc.date.available | 2022-11-16T02:07:38Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://hdl.handle.net/2433/277265 | - |
dc.description.abstract | Dietary sphingolipids such as glucosylceramide and sphingomyelin are known to improve the skin barrier function of damaged skin. In this study, we focused on free-ceramide prepared from soy sauce lees, which is a byproduct of soy sauce production. The effects of dietary soy sauce lees ceramide on the skin of normal mice were evaluated and compared with those of dietary maize glucosylceramide. We found that transepidermal water loss value was significantly suppressed by dietary supplementation with soy sauce lees ceramide as effectively as or more effectively than maize glucosylceramide. Although the content of total and each subclass of ceramide in the epidermis was not significantly altered by dietary sphingolipids, that of 12 types of ceramide molecules, which were not present in dietary sources, was significantly increased upon ingestion of maize glucosylceramide and showed a tendency to increase with soy sauce lees ceramide intake. In addition, the mRNA expression of ceramide synthase 4 and involucrin in the skin was downregulated by sphingolipids. This study, for the first time, demonstrated that dietary soy sauce lees ceramide enhances skin barrier function in normal hairless mice, although further studies are needed to clarify the molecular mechanism. | en |
dc.language.iso | eng | - |
dc.publisher | Japan Oil Chemists' Society | en |
dc.publisher.alternative | 日本油化学会 | ja |
dc.rights | © 2021 by Japan Oil Chemists' Society | en |
dc.rights | This article is licensed under a Creative Commons [Attribution 4.0 International] license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | ceramide | en |
dc.subject | glucosylceramide | en |
dc.subject | soy sauce lees | en |
dc.subject | maize | en |
dc.subject | skin barrier function | en |
dc.title | Dietary Ceramide Prepared from Soy Sauce Lees Improves Skin Barrier Function in Hairless Mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of Oleo Science | en |
dc.identifier.volume | 70 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1325 | - |
dc.identifier.epage | 1334 | - |
dc.relation.doi | 10.5650/jos.ess21128 | - |
dc.textversion | publisher | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 16H04923 | - |
datacite.awardNumber | 20H02931 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04923/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02931/ | - |
dc.identifier.pissn | 1345-8957 | - |
dc.identifier.eissn | 1347-3352 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 定性かつ定量的な解析に基づくスフィンゴ脂質の消化管吸収機構と体内動態の解明 | ja |
jpcoar.awardTitle | 吸収と代謝に着目したスフィンゴ脂質の皮膚バリア機能向上作用メカニズムの解明 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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