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タイトル: | Dietary Ceramide Prepared from Soy Sauce Lees Improves Skin Barrier Function in Hairless Mice |
著者: | Ohta, Kazushi Hiraki, Shinobu Miyanabe, Masakatsu Ueki, Tatsuro Manabe, Yuki ![]() ![]() ![]() Sugawara, Tatsuya ![]() ![]() ![]() |
著者名の別形: | 太田, 知志 真鍋, 祐樹 菅原, 達也 |
キーワード: | ceramide glucosylceramide soy sauce lees maize skin barrier function |
発行日: | 2021 |
出版者: | Japan Oil Chemists' Society |
誌名: | Journal of Oleo Science |
巻: | 70 |
号: | 9 |
開始ページ: | 1325 |
終了ページ: | 1334 |
抄録: | Dietary sphingolipids such as glucosylceramide and sphingomyelin are known to improve the skin barrier function of damaged skin. In this study, we focused on free-ceramide prepared from soy sauce lees, which is a byproduct of soy sauce production. The effects of dietary soy sauce lees ceramide on the skin of normal mice were evaluated and compared with those of dietary maize glucosylceramide. We found that transepidermal water loss value was significantly suppressed by dietary supplementation with soy sauce lees ceramide as effectively as or more effectively than maize glucosylceramide. Although the content of total and each subclass of ceramide in the epidermis was not significantly altered by dietary sphingolipids, that of 12 types of ceramide molecules, which were not present in dietary sources, was significantly increased upon ingestion of maize glucosylceramide and showed a tendency to increase with soy sauce lees ceramide intake. In addition, the mRNA expression of ceramide synthase 4 and involucrin in the skin was downregulated by sphingolipids. This study, for the first time, demonstrated that dietary soy sauce lees ceramide enhances skin barrier function in normal hairless mice, although further studies are needed to clarify the molecular mechanism. |
著作権等: | © 2021 by Japan Oil Chemists' Society This article is licensed under a Creative Commons [Attribution 4.0 International] license. |
URI: | http://hdl.handle.net/2433/277265 |
DOI(出版社版): | 10.5650/jos.ess21128 |
出現コレクション: | 学術雑誌掲載論文等 |
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