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  2. 060　医学研究科・医学部・医学部附属病院
  3. 学術雑誌掲載論文等
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    このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2433/279949
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dc.contributor.authorFukui, Sadahiroen
dc.contributor.authorUmeda, Katsutsuguen
dc.contributor.authorKubota, Hirohitoen
dc.contributor.authorIwai, Atsushien
dc.contributor.authorAkazawa, Ryoen
dc.contributor.authorIsobe, Kiyotakaen
dc.contributor.authorTanaka, Kuniakien
dc.contributor.authorKouzuki, Kagehiroen
dc.contributor.authorKawabata, Naokoen
dc.contributor.authorSaida, Satoshien
dc.contributor.authorKato, Itaruen
dc.contributor.authorHiramatsu, Hidefumien
dc.contributor.authorItatani, Yoshiroen
dc.contributor.authorFunakoshi, Taroen
dc.contributor.authorAdachi, Souichien
dc.contributor.authorTakita, Junkoen
dc.contributor.alternative福井, 貞弘ja
dc.contributor.alternative梅田, 雄嗣ja
dc.contributor.alternative窪田, 博仁ja
dc.contributor.alternative岩井, 篤ja
dc.contributor.alternative赤澤, 嶺ja
dc.contributor.alternative磯部, 清孝ja
dc.contributor.alternative田中, 邦明ja
dc.contributor.alternative上月, 景弘ja
dc.contributor.alternative川端, 奈央子ja
dc.contributor.alternative才田, 聡ja
dc.contributor.alternative加藤, 格ja
dc.contributor.alternative平松, 英文ja
dc.contributor.alternative板谷, 喜朗ja
dc.contributor.alternative船越, 太郎ja
dc.contributor.alternative足立, 壯一ja
dc.contributor.alternative滝田, 順子ja
dc.date.accessioned2023-03-24T01:48:16Z-
dc.date.available2023-03-24T01:48:16Z-
dc.date.issued2023-04-
dc.identifier.urihttp://hdl.handle.net/2433/279949-
dc.description.abstractPediatric colorectal cancer (CRC) is extremely rare, with little information about genetic profiles compared with adult CRC. Here, a 13-year-old male with advanced CRC underwent cancer gene panel testing, which detected 4 genetic abnormalities (MET amplification in addition to TP53, SMAD4, and CTNNA1 mutations) that might be associated with a poor prognosis. Based on high-level MET amplification, he received a multikinase inhibitor, cabozantinib, after failure of first-line and second-line chemotherapy, resulting in transient disease stabilization. Tailored targeted therapy based on molecular profiling can be an effective treatment strategy for rare cancers such as pediatric CRC.en
dc.language.isoeng-
dc.publisherWolters Kluwer Healthen
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Pediatric Hematology/Oncology. The published version of record [Fukui, Sadahiro MD*; Umeda, Katsutsugu MD*; Kubota, Hirohito MD*; Iwai, Atsushi MD*; Akazawa, Ryo MD*; Isobe, Kiyotaka MD*; Tanaka, Kuniaki MD*; Kouzuki, Kagehiro MD*; Kawabata, Naoko MD*; Saida, Satoshi MD*; Kato, Itaru MD*; Hiramatsu, Hidefumi MD*; Itatani, Yoshiro MD†; Funakoshi, Taro MD‡; Adachi, Souichi MD§; Takita, Junko MD*. Use of Cabozantinib to Treat MET-amplified Pediatric Colorectal Cancer. Journal of Pediatric Hematology/Oncology 45(3):p e423-e426, April 2023.] is available online at: https://doi.org/10.1097/MPH.0000000000002482en
dc.rightsThe full-text file will be made open to the public on 1 April 2024 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.en
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。en
dc.subjectcolorectal canceren
dc.subjectpediatricen
dc.subjectcancer gene panel testingen
dc.subjectMET inhibitoren
dc.subjectcabozantiniben
dc.titleUse of Cabozantinib to Treat MET-amplified Pediatric Colorectal Canceren
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleJournal of Pediatric Hematology/Oncologyen
dc.identifier.volume45-
dc.identifier.issue3-
dc.identifier.spagee423-
dc.identifier.epagee426-
dc.relation.doi10.1097/MPH.0000000000002482-
dc.textversionauthor-
dc.identifier.pmid35536994-
dcterms.accessRightsembargoed access-
datacite.date.available2024-04-01-
dc.identifier.pissn1077-4114-
dc.identifier.eissn1536-3678-
出現コレクション:学術雑誌掲載論文等

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