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ファイル | 記述 | サイズ | フォーマット | |
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j.xgen.2023.100292.pdf | 15.95 MB | Adobe PDF | 見る/開く |
タイトル: | Transposable elements are associated with the variable response to influenza infection |
著者: | Chen, Xun Pacis, Alain Aracena, Katherine A. Gona, Saideep Kwan, Tony Groza, Cristian Lin, Yen Lung Sindeaux, Renata Yotova, Vania Pramatarova, Albena Simon, Marie-Michelle Pastinen, Tomi Barreiro, Luis B. Bourque, Guillaume |
キーワード: | transposable elements Kruppel-associated box zinc finger proteins (KRAB-ZNFs) influenza infection variable response epigenetics gene regulation |
発行日: | 10-May-2023 |
出版者: | Elsevier BV |
誌名: | Cell Genomics |
巻: | 3 |
号: | 5 |
論文番号: | 100292 |
抄録: | Influenza A virus (IAV) infections are frequent every year and result in a range of disease severity. Here, we wanted to explore the potential contribution of transposable elements (TEs) to the variable human immune response. Transcriptome profiling in monocyte-derived macrophages from 39 individuals following IAV infection revealed significant inter-individual variation in viral load post-infection. Using transposase-accessible chromatin using sequencing (ATAC-seq), we identified a set of TE families with either enhanced or reduced accessibility upon infection. Of the enhanced families, 15 showed high variability between individuals and had distinct epigenetic profiles. Motif analysis showed an association with known immune regulators (e.g., BATFs, FOSs/JUNs, IRFs, STATs, NFkBs, NFYs, and RELs) in stably enriched families and with other factors in variable families, including KRAB-ZNFs. We showed that TEs and host factors regulating TEs were predictive of viral load post-infection. Our findings shed light on the role TEs and KRAB-ZNFs may play in inter-individual variation in immunity. |
記述: | インフルエンザ重症度に関連する転移因子を特定: マルチオミクス解析で見えた「動く遺伝子」の新たな役割. 京都大学プレスリリース. 2023-05-11. A multiomics approach provides insights into flu severity. 京都大学プレスリリース. 2023-05-11. |
著作権等: | © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. |
URI: | http://hdl.handle.net/2433/282091 |
DOI(出版社版): | 10.1016/j.xgen.2023.100292 |
PubMed ID: | 37228757 |
関連リンク: | https://ashbi.kyoto-u.ac.jp/ja/news/20230510_research-result_xun-chen/ https://ashbi.kyoto-u.ac.jp/news/20230510_research-result_xun-chen/ |
出現コレクション: | 学術雑誌掲載論文等 |
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