ダウンロード数: 59
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.cdev.2023.203845.pdf | 3.85 MB | Adobe PDF | 見る/開く |
タイトル: | Physical biomarkers for human hematopoietic stem and progenitor cells |
著者: | Tanaka, Motomu ![]() ![]() Thoma, Judith Poisa-Beiro, Laura Wuchter, Patrick Eckstein, Volker Dietrich, Sascha Pabst, Caroline Müller-Tidow, Carsten Ohta, Takao Ho, Anthony D. |
著者名の別形: | 田中, 求 |
キーワード: | Human hematopoietic stem and progenitor cell Acute myeloid leukemia Celsl adhesion Spatio-temporal dynamics Clinical agent |
発行日: | Jun-2023 |
出版者: | Elsevier BV |
誌名: | Cells & Development |
巻: | 174 |
論文番号: | 203845 |
抄録: | Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined in vitro niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs. |
著作権等: | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. |
URI: | http://hdl.handle.net/2433/284913 |
DOI(出版社版): | 10.1016/j.cdev.2023.203845 |
PubMed ID: | 37116713 |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス