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dc.contributor.author | Karunakaran, Kalyani B. | en |
dc.contributor.author | Amemori, Ken-ichi | en |
dc.contributor.alternative | 雨森, 賢一 | ja |
dc.date.accessioned | 2023-12-28T01:53:31Z | - |
dc.date.available | 2023-12-28T01:53:31Z | - |
dc.date.issued | 2023-12-13 | - |
dc.identifier.uri | http://hdl.handle.net/2433/286480 | - |
dc.description | 不安障害を引き起こす遺伝子群の解析から脳回路を特定 パニック障害などの原因究明に期待. 京都大学プレスリリース. 2023-12-20. | ja |
dc.description.abstract | Anxiety disorders (ADs) are the most common form of mental disorder that affects millions of individuals worldwide. Although physiological studies have revealed the neural circuits related to AD symptoms, how AD-associated genes are spatiotemporally expressed in the human brain still remains unclear. In this study, we integrated genome-wide association studies of four human AD subtypes—generalized anxiety disorder, social anxiety disorder, panic disorder, and obsessive-compulsive disorder—with spatial gene expression patterns. Our investigation uncovered a novel division among AD-associated genes, marked by significant and distinct expression enrichments in the cerebral nuclei, limbic, and midbrain regions. Each gene cluster was associated with specific anxiety-related behaviors, signaling pathways, region-specific gene networks, and cell types. Notably, we observed a significant negative correlation in the temporal expression patterns of these gene clusters during various developmental stages. Moreover, the specific brain regions enriched in each gene group aligned with neural circuits previously associated with negative decision-making and anxious temperament. These results suggest that the two distinct gene clusters may underlie separate neural systems involved in anxiety. As a result, our findings bridge the gap between genes and neural circuitry, shedding light on the mechanisms underlying AD-associated behaviors. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2023 | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Clinical genetics | en |
dc.subject | Molecular neuroscience | en |
dc.subject | Psychiatric disorders | en |
dc.title | Spatiotemporal expression patterns of anxiety disorder-associated genes | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Translational Psychiatry | en |
dc.identifier.volume | 13 | - |
dc.relation.doi | 10.1038/s41398-023-02693-y | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 385 | - |
dc.address | Institute for the Advanced Study of Human Biology, Kyoto University | en |
dc.address | Institute for the Advanced Study of Human Biology, Kyoto University | en |
dc.identifier.pmid | 38092764 | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/ja/news/20231220_research-result_kenichi-amemori/ | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 20H03555 | - |
datacite.awardNumber | 21K19428 | - |
datacite.awardNumber | 21H05169 | - |
datacite.awardNumber | 22H04998 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03555/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19428/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05169/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04998/ | - |
dc.identifier.eissn | 2158-3188 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 不安障害の制御を目指した霊長類ストリオソーム関連回路の機能解明 | ja |
jpcoar.awardTitle | 不安生成に関わるマカクザルの脳ネットワークの同定と刺激の非侵襲化 | ja |
jpcoar.awardTitle | 能動的推論の神経基盤の解明 | ja |
jpcoar.awardTitle | 敵対生成脳:マルチエージェント学習の計算理論、アルゴリズムとロボティクス応用 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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