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j.isci.2024.109107.pdf | 6.66 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Yi, Binbin | en |
dc.contributor.author | Tanaka, Yuri L. | en |
dc.contributor.author | Cornish, Daphne | en |
dc.contributor.author | Kosako, Hidetaka | en |
dc.contributor.author | Butlertanaka, Erika P. | en |
dc.contributor.author | Sengupta, Prabuddha | en |
dc.contributor.author | Lippincott-Schwartz, Jennifer | en |
dc.contributor.author | Hultquist, Judd F. | en |
dc.contributor.author | Saito, Akatsuki | en |
dc.contributor.author | Yoshimura, Shige H. | en |
dc.contributor.alternative | 田中, 友理 | ja |
dc.contributor.alternative | 小迫, 英尊 | ja |
dc.contributor.alternative | バトラー田中, 英里佳 | ja |
dc.contributor.alternative | 齊藤, 暁 | ja |
dc.contributor.alternative | 吉村, 成弘 | ja |
dc.date.accessioned | 2024-02-22T01:49:51Z | - |
dc.date.available | 2024-02-22T01:49:51Z | - |
dc.date.issued | 2024-03-15 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287064 | - |
dc.description | 新規HIV増殖阻害宿主因子の同定と作用メカニズムの解明. 京都大学プレスリリース. 2024-02-21. | ja |
dc.description.abstract | Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2024 The Author(s). | en |
dc.rights | This is an open access article under the CC BY license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Immunology | en |
dc.subject | Virology | en |
dc.subject | Biological sciences | en |
dc.title | Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | iScience | en |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 3 | - |
dc.relation.doi | 10.1016/j.isci.2024.109107 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 109107 | - |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Department of Veterinary Medicine, Faculty of Agriculture, University of Miyazaki | en |
dc.address | Division of Infectious Diseases, Northwestern University Feinberg School of Medicine; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health | en |
dc.address | Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University | en |
dc.address | Department of Veterinary Medicine, Faculty of Agriculture, University of Miyazaki | en |
dc.address | Howard Hughes Medical Institute | en |
dc.address | Howard Hughes Medical Institute | en |
dc.address | Division of Infectious Diseases, Northwestern University Feinberg School of Medicine; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health | en |
dc.address | Department of Veterinary Medicine, Faculty of Agriculture, University of Miyazaki; Center for Animal Disease Control, University of Miyazaki; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki | en |
dc.address | Graduate School of Biostudies, Kyoto University; Center for Living Systems Information Science (CeLiSIS), Kyoto University | en |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2024-02-21-0 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2589-0042 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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