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j.isci.2024.109107.pdf | 6.66 MB | Adobe PDF | 見る/開く |
タイトル: | Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism |
著者: | Yi, Binbin Tanaka, Yuri L. Cornish, Daphne Kosako, Hidetaka Butlertanaka, Erika P. Sengupta, Prabuddha Lippincott-Schwartz, Jennifer Hultquist, Judd F. Saito, Akatsuki Yoshimura, Shige H. |
著者名の別形: | 田中, 友理 小迫, 英尊 バトラー田中, 英里佳 齊藤, 暁 吉村, 成弘 |
キーワード: | Immunology Virology Biological sciences |
発行日: | 15-Mar-2024 |
出版者: | Elsevier BV |
誌名: | iScience |
巻: | 27 |
号: | 3 |
論文番号: | 109107 |
抄録: | Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy. |
記述: | 新規HIV増殖阻害宿主因子の同定と作用メカニズムの解明. 京都大学プレスリリース. 2024-02-21. |
著作権等: | © 2024 The Author(s). This is an open access article under the CC BY license. |
URI: | http://hdl.handle.net/2433/287064 |
DOI(出版社版): | 10.1016/j.isci.2024.109107 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-02-21-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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