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タイトル: | Characteristics of Acute Cartilage Response After Mechanical Loading in Patients with Early-Mild Knee Osteoarthritis |
著者: | Okada, Shogo Taniguchi, Masashi Yagi, Masahide https://orcid.org/0000-0002-1825-3570 (unconfirmed) Motomura, Yoshiki Okada, Sayaka Nakazato, Kaede Fukumoto, Yoshihiro Kobayashi, Masashi Kanemitsu, Kyoseki Ichihashi, Noriaki https://orcid.org/0000-0003-2508-2172 (unconfirmed) |
著者名の別形: | 岡田, 笙吾 谷口, 匡史 八木, 優英 本村, 芳樹 岡田, 紗也花 仲里, 楓 福元, 喜啓 市橋, 則明 |
キーワード: | Knee Cartilage Ultrasound Mechanical loading Osteoarthritis |
発行日: | May-2024 |
出版者: | Springer Nature |
誌名: | Annals of Biomedical Engineering |
巻: | 52 |
号: | 5 |
開始ページ: | 1326 |
終了ページ: | 1334 |
抄録: | This study determined whether the acute cartilage response, assessed by cartilage thickness and echo intensity, differs between patients with early-mild knee osteoarthritis (OA) and healthy controls. We recruited 56 women aged ≥ 50 years with Kellgren-Lawrence (KL) grade ≤ 2 (age, 70.6 ± 7.4 years; height, 153.7 ± 5.2 cm; weight, 51.9 ± 8.2 kg). Based on KL grades and knee symptoms, the participants were classified into control (KL ≤ 1, asymptomatic, n = 27) and early-mild knee OA groups (KL 1 and symptomatic, KL 2, n = 29). Medial femoral cartilage thickness and echo intensity were assessed using ultrasonographic B-mode images before and after treadmill walking (15 min, 3.3 km/h). To investigate the acute cartilage response, repeated-measures analysis of covariance (groups × time) with adjusted age, external knee moment impulse, steps during treadmill walking, and cartilage thickness at pre-walking was performed. A significant interaction was found at the tibiofemoral joint; after walking, the cartilage thickness was significantly decreased in the early-mild knee OA group compared to the control group (p = 0.002). At the patellofemoral joint, a significant main effect of time was observed, but no interaction was detected (p = 0.802). No changes in cartilage echo intensity at either the tibiofemoral or patellofemoral joints, and no interactions were noted (p = 0.295 and p = 0.063). As acute cartilage response after walking, the thickness of the medial tibiofemoral joint in the early-mild knee OA was significantly reduced than that in the control group. Thus, greater acute deformation after walking might be a feature found in patients with early-mild knee OA. |
著作権等: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10439-024-03456-6 The full-text file will be made open to the public on 08 February 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/287508 |
DOI(出版社版): | 10.1007/s10439-024-03456-6 |
PubMed ID: | 38329562 |
出現コレクション: | 学術雑誌掲載論文等 |
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