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タイトル: | The ascidian Mesp gene specifies heart precursor cells |
著者: | Satou, Yutaka ![]() ![]() ![]() Imai, Kaoru S. Satoh, Nori |
著者名の別形: | 佐藤, ゆたか 今井, 薫 佐藤, 矩行 |
キーワード: | Chordate Ciona savignyi Mesp Heart development |
発行日: | Jun-2004 |
出版者: | The Company of Biologists |
誌名: | Development |
巻: | 131 |
号: | 11 |
開始ページ: | 2533 |
終了ページ: | 2541 |
抄録: | Understanding the molecular basis of heart development is an important research area, because malformation of the cardiovascular system is among the most frequent inborn defects. Although recent research has identified molecules responsible for heart morphogenesis in vertebrates, the initial specification of heart progenitors has not been well characterized. Ascidians provide an appropriate experimental system for exploring this specification mechanism, because the lineage for the juvenile heart is well characterized, with B7.5 cells at the 110-cell stage giving rise to embryonic trunk ventral cells (TVCs) or the juvenile heart progenitors. Here, we show that Cs-Mesp, the sole ortholog of vertebrate Mesp genes in the ascidian Ciona savignyi, is specifically and transiently expressed in the embryonic heart progenitor cells (B7.5 cells). Cs-Mesp is essential for the specification of heart precursor cells, in which Nkx, HAND and HAND-like (NoTrlc) genes are expressed. As a result, knockdown of Cs-Mesp with specific morpholino antisense oligonucleotides causes failure of the development of the juvenile heart. Together with previous evidence obtained in mice, the present results suggest that a mechanism for heart specification beginning with Mespthrough Nkx and HAND is conserved among chordates. |
著作権等: | © 2004. Published by The Company of Biologists Ltd The full-text file will be made open to the public on 2 June 2005 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
URI: | http://hdl.handle.net/2433/287629 |
DOI(出版社版): | 10.1242/dev.01145 |
PubMed ID: | 15115756 |
出現コレクション: | 学術雑誌掲載論文等 |
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