<原著>第 2 篇肺癌手術時における選択的経リンパ行性制癌剤投与法の研究(選択的経リンパ行性制癌剤投与法に関する研究)

Abstract

In actual procedure of surgery for lung cancer, adequate dissection of mediastinal lymphatic metastases, especially in the contralateral mediastinum, is generally difficult, and hence we designed the following two methods of intralymphatic administration of anticancer agents during thoracotomy; (1) Injection into the subpleural lymphatics. (2) Injectino into the subcarinal lymph nodes. In 12 patients with non-oat cell lung cancer, Lipiodol-BLM (emulsified Bleomycin in Lipiodol) was administered into the subpleural lymphatics of the ipsilateral lower lobe during thoracotomy, and higher densities of BLM were detected in pulmonary hilar and mediastinal lymph nodes. In several instances, BLM was detected even in histologically involved lymph nodes. In another 8cases, in which Lipiodol-BLM was injected into subcarinal lymph nodes, radioopactity was found in not only ipsilateral mediastinal lymph nodes but also contralateral ones. With regard to the foresaid experimental study it is suggested that the intralymphatic administration will suppress the lymphatic micrometastases remaining after surgical intervention in lung cancer.