Classification and Analysis of Eukaryotic ABC Transporters in Complete Eukarya Genomes (MOLECULAR BIOLOGY AND INFORMATION-Biological Information Science)

Abstract

The ABC(ATP-Binding Cassette) transporters form a major class of active transporters which are widespread in archaea, bacteria, and eukarya. Most of eukaryotic ABC transporters are involved in exporting antibiotic drugs. In this study, first, we identified the eukaryotic ABC transporters in three complete eukarya genomes, S.cerevisie, C.elegans and D.melanogaster. Next, we classified the eukaryotic ABC transporters into the clusters of orthologs and paralogs using the hierarchical cluster analysis. In addition, we built Hidden Markov Models (HMMs) for individual clusters, and identified the orthologs of individual clusters in othrer genomes by using the HMMs.