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dc.contributor.authorKawabata, Takeoja
dc.contributor.authorSuzuki, Hideoja
dc.contributor.authorNagae, Yoshikazuja
dc.contributor.authorChen, Jianyongja
dc.contributor.authorFuji, Kaoruja
dc.date.accessioned2008-08-25T06:21:40Z-
dc.date.available2008-08-25T06:21:40Z-
dc.date.issued2001-03ja
dc.identifier.issn1342-0321ja
dc.identifier.urihttp://hdl.handle.net/2433/65272-
dc.description.abstractThe structure of enolate was long believed to be achiral. However, a chiral nonracemic enolate with a racemization barrier of 16 kcal/mol at -78 oC was found to be the crucial intermediate for the asymmetric -methylation of 1 to give 2 in 81% ee and 96% yield. The asymmetric -methylation occurs in other amino acid derivatives (Val, Leu, Trp, His, Tyr, Dopa) in 78-93% ee.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherInstitute for Chemical Research, Kyoto Universityja
dc.subjectchiral enolateja
dc.subjectdynamic chiralityja
dc.subjectasymmetric synthesisja
dc.subjectamino acidja
dc.subjectaxial chiralityja
dc.subject.ndc430ja
dc.titleA Chiral Nonracemic Enolate with Dynamic Axial Chirality: Direct Asymmetric Alkylation of α-Amino Acid Derivatives (SYNTHETIC ORGANIC CHEMISTRY-Fine Organic Synthesis)ja
dc.type.niitypeArticleja
dc.identifier.ncidAA11061308ja
dc.identifier.jtitleICR annual reportja
dc.identifier.volume7ja
dc.identifier.spage36ja
dc.identifier.epage37ja
dc.textversionpublisherja
dc.sortkey20ja
Appears in Collections:Vol.7 (2000)

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