化學構造と藥理作用

Abstract

The author discuss the primitive pharmaceutical actions where their fundamental processes are of physico-chemical mechanisms, and arrive at the following conclusions. (1) The logarithm of the lowest effective-concentration M can be represented by the addition of a constant Un particular to each group in the molecule. (2) The fundamental characteristic of pharmaceutical mechanism will be reasoned from the value of the additive constant and the equation. (3) There are two types of addition. One type has a center of action where the amount of the additive constant Un is large and based on pure chemical reactions and is represented by log M=U0+∑τnUn where τn is a steric constant. (4) The other type has no center and all groups contribute equally to the action where Un is comparably small and based on physico-chemical reactions, such as vaporization, dissolution and diffusion, and is represented by log M=∑σnUn where σn is a steric constant. We have confirmed these equations in many examples.