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タイトル: | インターフェロンα抵抗性進行腎細胞癌に対してインターフェロンαと低用量のSorafenibの併用療法が奏効したと考えられる1例 |
その他のタイトル: | Interferon Alpha and Half-Dose Sorafenib is an Effective Treatment Modality for Interferon Alpha-Resistant Metastatic Renal Cell Carcinoma : A Case Report |
著者: | 古谷, 信隆 釜井, 隆男 得居, 範子 阿部, 英行 深堀, 能立 吉田, 謙一郎 |
著者名の別形: | Furuya, Nobutaka Kamai, Takao Tokui, Noriko Abe, Hideyuki Fukabori, Yoshitatsu Yoshida, Ken-ichiro |
キーワード: | Interferon alpha Sorafenib Renal cell carcinoma Metastasis Combination |
発行日: | Jun-2009 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 55 |
号: | 6 |
開始ページ: | 323 |
終了ページ: | 326 |
抄録: | Metastatic renal cell carcinoma is notoriously resistant to chemotherapy and radiotherapy. Immunotherapy with interferon alpha is widely used for the disease, but its treatment effects are poor. A 69- year-old Japanese women presented with gross hematuria. Imaging studies revealed a left renal tumor, 12 cm in diameter, and multiple pulmonary and hepatic lesions. No abnormal laboratory data were observed other than anemia with Hb 9.2 g/dl. Performance status was 0. She underwent radial left nepherectomy. Pathological examination showed clear cell renal cell carcinoma with moderate histological differentiation (grade 2) and microscopic vessel invasion ; pT3aN0M1 (Pul, Hep). Memorial Sloon-Kettering Cancer Center classification was an intermediate risk due to anemia. She received interferon alpha, 5 million IU three times per week, postoperatively. In three months, hepatic lesions rapidly progressed although there was no interval change of pulmonary lesions. Then, the patient received interferon alpha at the same dose as described above and half-dose sorafenib, 400 mg per day. Grade 2 hypertension was under control by calcium channel blocker and the hand-foot syndrome was not obvious. No other grade3/4 drug-related adverse events were observed. In one month after combination therapy, not only pulmonary lesions but also hepatic lesions were smaller. She has received this combination therapy with stable disease for six months. Performance status was 1 with grade 1 fatigue. The doses of this regimen may be tolerable, and might be an available treatment option for interferon alpha-resistant advanced renal cancer. |
著作権等: | 許諾条件により本文は2010-07-01に公開 |
URI: | http://hdl.handle.net/2433/79913 |
PubMed ID: | 19588863 |
出現コレクション: | Vol.55 No.6 |
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