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タイトル: | 進行性前立腺癌に対するCyclophosphamideの大量間漱療法の経験 |
その他のタイトル: | Intermittent intravenous high-dose cyclophosphamide therapy for advanced prostatic cancer with distant metastasis |
著者: | 客野, 宮治 山口, 誓司 松宮, 清美 長船, 匡男 |
著者名の別形: | KYAKUNO, Miyaji YAMAGUCHI, Seiji MATSUMIYA, Kiyomi OSAFUNE, Masao |
キーワード: | Prostatic cancer Chemotherapy Cyclophosphamide |
発行日: | Nov-1989 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 35 |
号: | 11 |
開始ページ: | 1865 |
終了ページ: | 1869 |
抄録: | Twelve patients with advanced carcinoma of the prostate were treated with intravenous high-dose cyclophosphamide. All were hormone-resistant cases. At an interval of 3-4 weeks, cyclophosphamide was administered intravenously. The standard dosage of cyclophosphamide was 1, 000 mg/m2 and a 10% lower dose was administered to patients with liver dysfunction, anemia and elderly patients. The results of 10 patients were evaluable. One case showed objective partial response, 1 case was stable and 8 patients showed objective progression according to the NPCP efficacy evaluation standard. The overall response rate was 20%, which we did not consider satisfactory. As to toxicity of cyclophosphamide, one patient died of severe acute hepatic failure, but in others, complications were mild to tolerable. |
URI: | http://hdl.handle.net/2433/116754 |
PubMed ID: | 2618884 |
出現コレクション: | Vol.35 No.11 |
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