泌尿器科領域の悪性腫瘍における血清ferritinの検討(第2報)

Abstract

泌尿器科悪性腫瘍患者を対象に, 血清ferritinをSPAC, RIA-Gnostにより測定し, tumor markerとしての意義を検討した.RIA-Gnostにおける正常男子の血清ferritin値は, 142.5±67.5 ng/ml (n=58), 正常女子は49.6±28.8 ng/ml (n=76)であった.膀胱癌患者22例の血清ferritin値は, 両測定法において正常よりやや低値を示し, 陽性率はそれぞれ30%前後であった.前立腺癌患者22例においては, 両測定法とも陽性率は45.5%であり, RIA-Gnostにおいては, 前立腺癌患者の血清ferritin値は高く, 正常男子との間にP<0.1%で有意差を認めた.腎癌患者6例の血清ferritin値は, RIA-Gnostにおいて, P<0.1%で有意に高く100%の陽性率であった.SPACにおいては陽性率67%であった.血清ferritinは, とくにRIA-Gnostにおいて腎癌患者のtumor markerとして意義を認めた

By means of the RIA-Gnost Ferritin and Spac Ferritin kits, the serum ferritin levels of patients with some urological malignant diseases were quantitated; and, the clinical significance of these values as a tumor marker was discussed. The normal (reference) level in serum obtained by the RIA-Gnost kit was 142.5 +/- 67.5 ng/ml (n = 58) for healthy males and 49.6 +/- 28.8 ng/ml (n = 76) for healthy females. The assay values for 22 cases of bladder cancer by both kits were somewhat lower than the normal range, and the positive rates presented were around 30%, being in rough agreement with each other. The positive rate for 22 patients with prostatic cancer was 45.5% by either method. The assay values obtained by the RIA-Gnost kit was higher and differed significantly (p less than 0.1%) from those obtained on healthy males. Furthermore, the same tendency was found in 6 cases of renal cancer. The assay values of RIA-Gnost were significantly higher (p less than 0.1%) than normal; and, the positive rate was 100% for RIA-Gnost and 67% for Spac . In conclusion, serum ferritin determination especially that by the RIA-Gnost kit proved to be a useful and significant tumor marker for the detection of renal cancer.