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Title: The in vivo performance of polyvinyl alcohol macro-encapsulated islets.
Authors: Qi, Zhi
Shen, Yanna
Yanai, Goichi
Yang, Kaichiang
Shirouzu, Yasumasa
Hiura, Akihito
Sumi, Shoichiro  kyouindb  KAKEN_id
Author's alias: 角, 昭一郎
Keywords: Polyvinyl alcohol (PVA)
Macro-encapsulated islets (MEIs)
Islet cryopreservation
Islet transplantation
Issue Date: May-2010
Publisher: Elsevier Ltd.
Journal title: Biomaterials
Volume: 31
Issue: 14
Start page: 4026
End page: 4031
Abstract: Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA) macro-encapsulated islets (MEI) to treat type 1 DM without any immunotherapy. The present study examined their beneficial effects on islet cryopreservation. PVA MEI of Wistar rats were divided into three groups of 1-day, 7-day and 30-day cryopreservation at -80 degrees C. The 30-day group showed a lower recovery rate of the islet number and impaired insulin release in comparison to the 1-day group, whereas no significant differences of the in vitro results were observed between the 1-day and 7-day groups. The MEI transplantation recipient mice in the 1-day and 7-day groups reached normoglycemia for a 4-week observation period, and the recipients in 30-day group also showed a significant decrease followed by a slightly higher non-fasting blood glucose level. These results suggest that the PVA MEI are useful for islet long-term cryopreservation, and that the use of cryopreserved PVA MEI may, therefore, be a promising modality for performing DM therapy.
Rights: © 2010 Elsevier Ltd.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.biomaterials.2010.01.088
PubMed ID: 20149430
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