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j.biomaterials.2010.01.088.pdf | 572.91 kB | Adobe PDF | 見る/開く |
タイトル: | The in vivo performance of polyvinyl alcohol macro-encapsulated islets. |
著者: | Qi, Zhi Shen, Yanna Yanai, Goichi Yang, Kaichiang Shirouzu, Yasumasa Hiura, Akihito Sumi, Shoichiro |
著者名の別形: | 角, 昭一郎 |
キーワード: | Polyvinyl alcohol (PVA) Macro-encapsulated islets (MEIs) Islet cryopreservation Islet transplantation |
発行日: | May-2010 |
出版者: | Elsevier Ltd. |
誌名: | Biomaterials |
巻: | 31 |
号: | 14 |
開始ページ: | 4026 |
終了ページ: | 4031 |
抄録: | Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA) macro-encapsulated islets (MEI) to treat type 1 DM without any immunotherapy. The present study examined their beneficial effects on islet cryopreservation. PVA MEI of Wistar rats were divided into three groups of 1-day, 7-day and 30-day cryopreservation at -80 degrees C. The 30-day group showed a lower recovery rate of the islet number and impaired insulin release in comparison to the 1-day group, whereas no significant differences of the in vitro results were observed between the 1-day and 7-day groups. The MEI transplantation recipient mice in the 1-day and 7-day groups reached normoglycemia for a 4-week observation period, and the recipients in 30-day group also showed a significant decrease followed by a slightly higher non-fasting blood glucose level. These results suggest that the PVA MEI are useful for islet long-term cryopreservation, and that the use of cryopreserved PVA MEI may, therefore, be a promising modality for performing DM therapy. |
著作権等: | © 2010 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/139506 |
DOI(出版社版): | 10.1016/j.biomaterials.2010.01.088 |
PubMed ID: | 20149430 |
出現コレクション: | 学術雑誌掲載論文等 |
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