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タイトル: Importance of water entropy in rotation mechanism of F1-ATPase
著者: Yoshidome, Takashi
著者名の別形: 吉留, 崇
キーワード: Asymmetric packing
water
hydration entropy
integral equation theory
morphometric approach
発行日: 2011
出版者: Biophysical Society of Japan
誌名: BIOPHYSICS
巻: 7
開始ページ: 113
終了ページ: 122
抄録: We briefly review our theoretical study on the rotation scheme of F1-ATPase. In the scheme, the key factor is the water entropy which has been shown to drive a variety of self-assembly processes in biological systems. We decompose the crystal structure of F1-ATPase into three sub-complexes each of which is composed of the γ subunit, one of the β subunits, and two α subunits adjacent to them. The βE, βTP, and βDP subunits are involved in the sub-complexes I, II, and III, respectively. We calculate the hydration entropy of each sub-complex using a hybrid of the integral equation theory for molecular liquids and the morphometric approach. It is found that the absolute value of the hydration entropy follows the order, sub-complex I > sub-complex II > sub-complex III. Moreover, the differences are quite large, which manifests highly asymmetrical packing of F1-ATPase. In our picture, this asymmetrical packing plays crucially important roles in the rotation of the γ subunit. We discuss how the rotation is induced by the water-entropy effect coupled with such chemical processes as ATP binding, ATP hydrolysis, and release of the products.
著作権等: (c) 2011 THE BIOPHYSICAL SOCIETY OF JAPAN
URI: http://hdl.handle.net/2433/152166
DOI(出版社版): 10.2142/biophysics.7.113
出現コレクション:学術雑誌掲載論文等

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