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Title: A new theoretical approach to biological self-assembly
Authors: Kinoshita, Masahiro  kyouindb  KAKEN_id
Author's alias: 木下, 正弘
Keywords: Solvation entropy
Biological self-assembly
Protein folding
Protein denaturation
Molecular recognition
ATP-driven protein
Integral equation theory
Morphometric approach
Issue Date: Sep-2013
Publisher: Springer Berlin Heidelberg
Journal title: Biophysical Reviews
Volume: 5
Issue: 3
Start page: 283
End page: 293
Abstract: Upon biological self-assembly, the number of accessible translational configurations of water in the system increases considerably, leading to a large gain in water entropy. It is important to calculate the solvation entropy of a biomolecule with a prescribed structure by accounting for the change in water–water correlations caused by solute insertion. Modeling water as a dielectric continuum is not capable of capturing the physical essence of the water entropy effect. As a reliable tool, we propose a hybrid of the angle-dependent integral equation theory combined with a multipolar water model and a morphometric approach. Using our methods wherein the water entropy effect is treated as the key factor, we can elucidate a variety of processes such as protein folding, cold, pressure, and heat denaturating of a protein, molecular recognition, ordered association of proteins such as amyloid fibril formation, and functioning of ATP-driven proteins.
Rights: The final publication is available at Springer via
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1007/s12551-013-0100-8
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