ダウンロード数: 258
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s12551-013-0100-8.pdf | 653.24 kB | Adobe PDF | 見る/開く |
タイトル: | A new theoretical approach to biological self-assembly |
著者: | Kinoshita, Masahiro |
著者名の別形: | 木下, 正弘 |
キーワード: | Solvation entropy Biological self-assembly Protein folding Protein denaturation Molecular recognition ATP-driven protein Integral equation theory Morphometric approach |
発行日: | Sep-2013 |
出版者: | Springer Berlin Heidelberg |
誌名: | Biophysical Reviews |
巻: | 5 |
号: | 3 |
開始ページ: | 283 |
終了ページ: | 293 |
抄録: | Upon biological self-assembly, the number of accessible translational configurations of water in the system increases considerably, leading to a large gain in water entropy. It is important to calculate the solvation entropy of a biomolecule with a prescribed structure by accounting for the change in water–water correlations caused by solute insertion. Modeling water as a dielectric continuum is not capable of capturing the physical essence of the water entropy effect. As a reliable tool, we propose a hybrid of the angle-dependent integral equation theory combined with a multipolar water model and a morphometric approach. Using our methods wherein the water entropy effect is treated as the key factor, we can elucidate a variety of processes such as protein folding, cold, pressure, and heat denaturating of a protein, molecular recognition, ordered association of proteins such as amyloid fibril formation, and functioning of ATP-driven proteins. |
著作権等: | The final publication is available at Springer via http://dx.doi.org/10.1007/s12551-013-0100-8 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/189841 |
DOI(出版社版): | 10.1007/s12551-013-0100-8 |
PubMed ID: | 28510109 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。