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タイトル: | Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review |
著者: | Kikukawa, Hiroshi Sakuradani, Eiji Ando, Akinori https://orcid.org/0000-0002-8359-7441 (unconfirmed) Shimizu, Sakayu Ogawa, Jun https://orcid.org/0000-0003-2741-621X (unconfirmed) |
著者名の別形: | 菊川, 寛史 櫻谷, 英治 安藤, 晃規 清水, 昌 小川, 順 |
キーワード: | Arachidonic acid Mortierella alpina Molecular breeding Fatty acid desaturase |
発行日: | May-2018 |
出版者: | Elsevier BV |
誌名: | Journal of Advanced Research |
巻: | 11 |
開始ページ: | 15 |
終了ページ: | 22 |
抄録: | The filamentous fungus Mortierella alpina 1S-4 is capable of accumulating a large amount of triacylglycerol containing C20 polyunsaturated fatty acids (PUFAs). Indeed, triacylglycerol production by M. alpina 1S-4 can reach 20 g/L of culture broth, and the critical cellular signaling and structural PUFA arachidonic acid (ARA) comprises 30%–70% of the total fatty acid. The demonstrated health benefits of functional PUFAs have in turn encouraged the search for rich sources of these compounds, including fungal strains showing enhanced production of specific PUFAs. Screening for mutants and targeted gene manipulation of M. alpina 1S-4 have elucidated the functions of various enzymes involved in PUFA biosynthesis and established lines with improved PUFA productivity. In some cases, these strains have been used for indistrial-scale production of PUFAs, including ARA. In this review, we described practical ARA production through mutant breeding, functional analyses of genes encoding enzymes involved in PUFA biosynthesis, and recent advances in the production of specific PUFAs through molecular breeding of M. alpina 1S-4. |
著作権等: | © 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/231175 |
DOI(出版社版): | 10.1016/j.jare.2018.02.003 |
PubMed ID: | 30034872 |
出現コレクション: | 学術雑誌掲載論文等 |
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