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タイトル: Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review
著者: Kikukawa, Hiroshi
Sakuradani, Eiji
Ando, Akinori
Shimizu, Sakayu
Ogawa, Jun  kyouindb  KAKEN_id
著者名の別形: 菊川, 寛史
櫻谷, 英治
安藤, 晃規
清水, 昌
小川, 順
キーワード: Arachidonic acid
Mortierella alpina
Molecular breeding
Fatty acid desaturase
発行日: May-2018
出版者: Elsevier BV
誌名: Journal of Advanced Research
巻: 11
開始ページ: 15
終了ページ: 22
抄録: The filamentous fungus Mortierella alpina 1S-4 is capable of accumulating a large amount of triacylglycerol containing C20 polyunsaturated fatty acids (PUFAs). Indeed, triacylglycerol production by M. alpina 1S-4 can reach 20 g/L of culture broth, and the critical cellular signaling and structural PUFA arachidonic acid (ARA) comprises 30%–70% of the total fatty acid. The demonstrated health benefits of functional PUFAs have in turn encouraged the search for rich sources of these compounds, including fungal strains showing enhanced production of specific PUFAs. Screening for mutants and targeted gene manipulation of M. alpina 1S-4 have elucidated the functions of various enzymes involved in PUFA biosynthesis and established lines with improved PUFA productivity. In some cases, these strains have been used for indistrial-scale production of PUFAs, including ARA. In this review, we described practical ARA production through mutant breeding, functional analyses of genes encoding enzymes involved in PUFA biosynthesis, and recent advances in the production of specific PUFAs through molecular breeding of M. alpina 1S-4.
著作権等: © 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/231175
DOI(出版社版): 10.1016/j.jare.2018.02.003
出現コレクション:学術雑誌掲載論文等

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