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Title: Classification and Analysis of Eukaryotic ABC Transporters in Complete Eukarya Genomes (MOLECULAR BIOLOGY AND INFORMATION-Biological Information Science)
Authors: Igarashi, Yoshinobu
Kanehisa, Minoru
Keywords: ABC transporter
Hidden Markov Model
Bioinformatics
Issue Date: Mar-2001
Publisher: Institute for Chemical Research, Kyoto University
Journal title: ICR Annual Report
Volume: 7
Start page: 52
End page: 53
Abstract: The ABC(ATP-Binding Cassette) transporters form a major class of active transporters which are widespread in archaea, bacteria, and eukarya. Most of eukaryotic ABC transporters are involved in exporting antibiotic drugs. In this study, first, we identified the eukaryotic ABC transporters in three complete eukarya genomes, S.cerevisie, C.elegans and D.melanogaster. Next, we classified the eukaryotic ABC transporters into the clusters of orthologs and paralogs using the hierarchical cluster analysis. In addition, we built Hidden Markov Models (HMMs) for individual clusters, and identified the orthologs of individual clusters in othrer genomes by using the HMMs.
URI: http://hdl.handle.net/2433/65264
Appears in Collections:Vol.7 (2000)

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